Optimization Design of Flexible Neural Electrodes Based on Orthogonal Experimental Method

doi:10.16183/j.cnki.jsjtu.2019.068

Abstract

Abstract:

In order to optimize the design of flexible neural electrodes, three parameters of elastic modulus, electrode thickness, and wedge angle are comprehensively studied. The experimental groups are established based on orthogonal experimental design. The maximum strain of brain tissue in different experimental groups are evaluated by ANSYS. In addition, a new hybrid flexible electrode is designed based on the stimulation results. The experimental results reveal that when elastic modulus is 8.5GPa, thickness is 15μm and wedge angle is 45°, the maximum strain of brain tissue due to micromotion is the smallest, i.e., 5.5627×10^-2. Moreover, a sandwich-type hybrid flexible neural electrode is designed with an elastic modulus of 8.5GPa on both sides and an elastic modulus of 5.5GPa in the intermediate layer. The sandwich-type structure can effectively reduce micromotion damage and implant deformation compared to the traditional electrode.

Key words: flexible electrode, finite element, orthogonal experiment, optimized design

CLC Number:

R318.01
Q66

XIE Jie, ZHANG Wenguang, YIN Xuele, LI Wei. Optimization Design of Flexible Neural Electrodes Based on Orthogonal Experimental Method[J]. Journal of Shanghai Jiaotong University, 2020, 54(8): 785-791.

Figures/Tables 12

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参数	取值
ρ/(g·cm^-3)	1.0425
μ/Pa	5160
k	6.95
G₁	0.5837
G₂	0.2387
τ₁/s	0.02571
τ₂/s	0.02570

试验序号	试验参数			试验方案
试验序号	E_i	h_i	α_i	试验方案
1	E₁	h₁	α₁	E₁h₁α₁
2	E₁	h₂	α₂	E₁h₂α₂
3	E₁	h₃	α₃	E₁h₃α₃
4	E₂	h₂	α₃	E₂h₂α₃
5	E₂	h₃	α₁	E₂h₃α₁
6	E₂	h₁	α₂	E₂h₁α₂
7	E₃	h₃	α₂	E₃h₃α₂
8	E₃	h₁	α₃	E₃h₁α₃
9	E₃	h₂	α₁	E₃h₂α₁

试验序号	E_i/GPa	h_i/μm	α_i/(°)	ε_i×10²
14	5.5-8.5-5.5	15	45	5.4063
15	8.5-5.5-8.5	15	45	3.8834