J Shanghai Jiaotong Univ Sci ›› 2025, Vol. 30 ›› Issue (1): 130-135.doi: 10.1007/s12204-023-2590-2
刘玉川1,李浩1,唐宇龙1,梁杜娟2,谭佳3,符玥1,李勇明4
收稿日期:
2022-11-11
接受日期:
2022-12-01
出版日期:
2025-01-28
发布日期:
2025-01-28
LIU Yuchuan1 (张轶伦), LI Hao1 (徐思坤), TANG Yulong1 (徐 捷), LIANG Dujuan2 (曾学奇), TAN Jia3 (李 铮), FU Yue1 (谢 驰), LI Yongming4∗ (谢 驰)
Received:
2022-11-11
Accepted:
2022-12-01
Online:
2025-01-28
Published:
2025-01-28
摘要: 脑年龄是一种有效诊断阿尔兹海默症(AD)的生物标记物。针对现有的脑年龄检测方法与AD是大脑加速老化的生物学假说相悖的问题,提出了一种互信息-支持向量回归(MI-SVR)的脑年龄检测模型。首先,根据AD的生物学假说引入年龄偏差;其次,基于互信息准则设计了适应度函数;然后,支持向量回归和适应度函数分别用于获取受试者的脑年龄和适应度值,最佳年龄偏差则通过查找最大适应度值获得;最后,比较于现有的一些脑年龄检测方法。实验结果表明,提出的方法所获得的脑年龄具有更好的可分性,能更好反映AD的加速衰老进程,更有助于提升AD的诊断准确率。
中图分类号:
刘玉川1,李浩1,唐宇龙1,梁杜娟2,谭佳3,符玥1,李勇明4. 基于互信息-支持向量回归的阿尔兹海默症磁共振影像脑年龄检测[J]. J Shanghai Jiaotong Univ Sci, 2025, 30(1): 130-135.
LIU Yuchuan1 (刘玉川), LI Hao1 (李浩), TANG Yulong1 (唐宇龙), LIANG Dujuan2 (梁杜娟), TAN Jia3 (谭佳), FU Yue1 (符玥), LI Yongming4∗ (李勇明). Brain Age Detection of Alzheimer’s Disease Magnetic Resonance Images Based on Mutual Information - Support Vector Regression[J]. J Shanghai Jiaotong Univ Sci, 2025, 30(1): 130-135.
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