J Shanghai Jiaotong Univ Sci ›› 2021, Vol. 26 ›› Issue (3): 272-283.doi: 10.1007/s12204-021-2293-5

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Research Update on Bioreactors Used in Tissue Engineering

WANG Wenhao1,2 (王文豪), DENG Qian1 (邓迁), LI Tao2 (李涛), LIU Yuehua3 (刘月华), LIU Yang2 (刘洋), SUN Yeye4 (孙叶叶), DENG Changxu2 (邓昌旭), ZHOU Xiaojun5 (周小军), MA Zhenjiang2 (马振江), QIANG Lei1 (强磊), WANG Jinwu1,2(王金武), DAI Kerong1,2 (戴尅戎)   

  1. (1. College of Medicine, Southwest Jiaotong University, Chengdu 610031, China; 2. Shanghai Key Laboratory of
    Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People’s Hospital,
    Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China; 3. Department of Obstetrics and
    Gynecology, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China;
    4. Hunan Polytechnic of Environment and Biology, Hengyang 422000, Hunan, China;
    5. College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China)
  • 出版日期:2021-06-28 发布日期:2021-06-02
  • 通讯作者: WANG Jinwu1,2(王金武), DAI Kerong1,2 (戴尅戎) E-mail:wangjw@shsmu.edu.cn, krdai@163.com
  • 基金资助:
    the National Key Research and Development
    Program of China (No. 2018YFB1105600)

Research Update on Bioreactors Used in Tissue Engineering

WANG Wenhao1,2(王文豪), DENG Qian1 (邓迁), LI Tao2 (李涛), LIU Yuehua3 (刘月华), LIU Yang2 (刘洋), SUN Yeye4 (孙叶叶), DENG Changxu2 (邓昌旭), ZHOU Xiaojun5 (周小军), MA Zhenjiang2 (马振江), QIANG Lei1 (强磊), WANG Jinwu1,2(王金武), DAI Kerong1,2 (戴尅戎)   

  1. (1. College of Medicine, Southwest Jiaotong University, Chengdu 610031, China; 2. Shanghai Key Laboratory of
    Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People’s Hospital,
    Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China; 3. Department of Obstetrics and
    Gynecology, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China;
    4. Hunan Polytechnic of Environment and Biology, Hengyang 422000, Hunan, China;
    5. College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China)
  • Online:2021-06-28 Published:2021-06-02
  • Contact: WANG Jinwu1,2(王金武), DAI Kerong1,2 (戴尅戎) E-mail:wangjw@shsmu.edu.cn, krdai@163.com
  • Supported by:
    the National Key Research and Development
    Program of China (No. 2018YFB1105600)

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摘要： Owing to the paucity of donor organs and their acute rejection by the immune system after transplantation,  advanced organ failure is one of the major challenges faced by the medical community. Static culturing  used for synthesising tissues and organs cannot simulate the in vivo mechanical and biochemical signals; therefore,  such artificial organs fail to maintain effective functional activity following transplantation. Tissue engineering can  overcome these hurdles by successfully enabling regeneration of tissues and organs in vitro. Bioreactors are pivotal  in the development and generation of engineered biological products. They simulate the in vivo microenvironment  of tissue growth while also providing various mechanical stimuli and biochemical signals to stem cells to effectively  generate transplantable organs or tissues. Various designs and types of bioreactors, their applications, and future  research prospects are summarised, which promote functional tissue engineering.

Abstract: Owing to the paucity of donor organs and their acute rejection by the immune system after transplantation,  advanced organ failure is one of the major challenges faced by the medical community. Static culturing  used for synthesising tissues and organs cannot simulate the in vivo mechanical and biochemical signals; therefore,  such artificial organs fail to maintain effective functional activity following transplantation. Tissue engineering can  overcome these hurdles by successfully enabling regeneration of tissues and organs in vitro. Bioreactors are pivotal  in the development and generation of engineered biological products. They simulate the in vivo microenvironment  of tissue growth while also providing various mechanical stimuli and biochemical signals to stem cells to effectively  generate transplantable organs or tissues. Various designs and types of bioreactors, their applications, and future  research prospects are summarised, which promote functional tissue engineering.

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