J Shanghai Jiaotong Univ Sci ›› 2023, Vol. 28 ›› Issue (4): 468-.doi: 10.1007/s12204-022-2507-5

• • 上一篇    


胡颖涵1, 朱泽宇1, 滕 林2, 何雨石3, 邹德荣1 , 陆家瑜1   

  1. (1.上海交通大学附属第六人民医院口腔科,上海200233;2. 上海交通大学 电气绝缘与热老化重点实验室,上海200240;3. 上海交通大学 上海电化学能源装置研究中心,上海200240)
  • 收稿日期:2021-04-30 接受日期:2021-09-08 出版日期:2023-07-28 发布日期:2023-07-31

Applications of Polypeptide Hydrogels in Cartilage-Regeneration Engineering

HU Yinghan1 (胡颖涵),ZHU Zegu1 (朱泽宇), TENG Lin2 (滕林), HE Yushi3 (何雨石),ZOU Derong1 (邹德荣),LU Jiayu1*(陆家瑜)   

  1. (1. Department of Stomatology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China; 2. Shanghai Key Laboratory of Electrical Insulation and Thermal Aging, Shanghai Jiao Tong University, Shanghai 200240, China; 3. Shanghai Electrochemical Energy Devices Research Centre, Shanghai Jiao Tong University, Shanghai 200240, China)
  • Received:2021-04-30 Accepted:2021-09-08 Online:2023-07-28 Published:2023-07-31

摘要: 关节软骨缺损被认为与骨关节炎的发展有关。相关组织再生的研究在骨关节炎的治疗中具有重要意义。用于软骨再生的支架应具有良好的组织相容性,力学性能及无细胞毒性,并能促进种子细胞的增殖和分化。多肽水凝胶中多肽序列的不同组合使其具有优异的生物可降解性和准确模拟软骨细胞细胞外基质的独特特性,以维持软骨表型的稳定性及促进关节透明软骨的再生。因此,多肽水凝胶在软骨再生中的应用前景广阔。本文系统综述了多肽水凝胶在软骨再生工程中的研究进展。对这些材料的特点、局限性和前景进行了评价。

关键词: 多肽水凝胶,聚氨基酸,关节软骨,软骨修复,软骨再生工程

Abstract: Articular cartilage defects are considered to be associated with the development of osteoarthritis. Research on relevant tissue regeneration is important in the treatment of osteoarthritis. The scaffolds applied incartilage regeneration should have good histocompatibility and mechanical properties, as well as no cytotoxicity,and promote the proliferation and differentiation of seed cells. Different combinations of peptide sequences inpolypeptide hydrogels endow them with unique characteristics including excellent biodegradability and accuratesimulation of the extracellular matrix of chondrocytes to maintain the stability of the chondrogenic phenotypeand facilitate articular hyaline cartilage regeneration. Thus, the application of polypeptide hydrogels for cartilage regeneration has a bright future. In this study, the research progress of polypeptide hydrogels used incartilage-regeneration engineering is systematically reviewed. The characteristics, limitations, and prospects ofthese materials are evaluated.

Key words: polypeptide hydrogel, poly amino acid, articular cartilage, cartilage repair, cartilage-regeneration engineering