Sirtuin Functions in the Brain: From Physiological to Pathological Aspects
SHAO Jia-xiang1,2,3 (邵家骧), ZHANG Ting-ting2,3 (张婷婷), LIU Teng-yuan2,3 (刘腾远), QUAN Yi-zhou1,2,3 (全亦周), LI Fan2,3 (李凡), LIU Jie1,2,3 (刘杰),YANG Xiao2,3 (杨霄), XIE Qian2,3 (谢谦), XIA Wei-liang1,2,3* (夏伟梁)
2014, 19 (6):
Sirtuins are a family of nicotinamide adenine dinucleotide (NAD+) dependent deacetylases involved
in multiple biological functions including metabolism, inflammation, stress resistance and aging. In mammals,
there are seven members (Sirt1—Sirt7), with diversities in their subcellular localizations and enzymatic activities.
Here, we review the functions of sirtuins, with a focus on their roles in normal brain physiology such as neural
development regulation, body homeostasis maintenance, and memory formation. We also discuss the role of
sirtuins in a variety of brain diseases including stroke, Alzheimer’s, Parkinson’s, and motor neuron dysfunction.
Because of the emerging functions of sirtuins in brain physiology and pathology, drugs targeting sirtuins may offer
potential therapeutic values for brain disorders.
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