Exploration of Intrafascicular Vagus Nerve Stimulation on Blood Pressure Reduction

doi:10.1007/s12204-024-2767-3

Abstract

Abstract: The vagus nerve plays a pivotal role in regulating blood pressure, making vagus nerve stimulation a promising therapy for refractory hypertension. Nevertheless, most current research on vagus nerve stimulation for hypertension regulation employs rigid electrodes outside the nerve bundle, with limited exploration into the electrical stimulation paradigms. In this study, we employed the carbon nanotube yarn electrode, a flexible electrode, implanted in the left vagus nerve of rats to compare the modulatory effects of duty cycle and pulse width stimulation paradigms. Furthermore, we conducted a quantitative electrical stimulation experiment using the optimized duty cycle paradigm. The result showed that low-frequency stimulation yielded superior blood pressure regulation, whereas high-frequency stimulation resulted in apnea. In conclusion, intrafascicular vagus nerve stimulation with the duty-cycle paradigm demonstrated superior efficacy in reducing blood pressure compared to the pulse-width paradigm, with an optimal duty cycle identified at 20%. These findings offer valuable insights for optimizing vagus nerve stimulation protocols in the treatment of hypertension.

Key words: vagus nerve stimulation, hypertension, intrafascicular electrodes

摘要： 迷走神经在调节血压中起着关键作用，使迷走神经刺激成为治疗难治性高血压的一种很有前景的治疗方法。目前关于迷走神经刺激调节高血压的研究大多采用神经束外的刚性电极，对电刺激范式的探索有限。本研究采用柔性电极碳纳米管纤维电极植入大鼠左侧迷走神经，比较了占空比和脉宽刺激范式对血压的调节作用。此外，使用优化的占空比范式进行了定量电刺激实验。结果表明：低频刺激对血压的调节效果较好，而高频刺激导致呼吸暂停。与脉宽模式相比，束内迷走神经刺激在降低血压方面表现出更好的效果，最佳占空比为20%。这些发现为优化迷走神经刺激治疗高血压的方案提供了有价值的见解。

关键词: 迷走神经刺激，高血压，神经束内电极

CLC Number:

R318

Tian Haoyang, Gu Mingcheng, Li Runhuan, Jin Mingyu, Peng Wei, Sui Xiaohong. Exploration of Intrafascicular Vagus Nerve Stimulation on Blood Pressure Reduction[J]. J Shanghai Jiaotong Univ Sci, 2025, 30(4): 702-708.

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