Animal Experiment of Viscose Carbon Fiber Based C/C Composites
Applied in Bone Fracture Intramedullary Fixation

doi:10.1007/s12204-012-1321-x

Journal of shanghai Jiaotong University (Science) ›› 2012, Vol. 17 ›› Issue (5): 537-540.doi: 10.1007/s12204-012-1321-x

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Animal Experiment of Viscose Carbon Fiber Based C/C Composites Applied in Bone Fracture Intramedullary Fixation

CAO Ning1* (曹宁), WANG Wen-bo2 (王文波), DONG Jian-wen2 (董建文)

(1. College of Mechanical and Electronic Engineering, China University of Petroleum, Qingdao 266580, Shandong, China; 2. No. 2 Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250001, China)
(1. College of Mechanical and Electronic Engineering, China University of Petroleum, Qingdao 266580, Shandong, China; 2. No. 2 Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250001, China)

Online:2012-10-30 Published:2012-11-16
Contact: CAO Ning1* (曹宁) E-mail:caoning1982@gmail.com

Abstract

Abstract: The animal experiment of viscose carbon fiber based C/C composites applied in bone defection intramedullary fixation was carried out in New Zealand white rabbits. The histological observation on the 100th day after surgical operation indicated that the experimental animals recovered well and the bone defect area was reconstructed by new bone trabecula. Immunohistochemical observation of leukocyte common antigen and macrophage suggested that intramedullary fixation materials did not induct any chronic toxicity reactions such as inflammatory reactions, macrophage reactions and formation of granulation tissue. The tissue compatibility of this material was excellent. Meanwhile, the impurity element species and the biological toxic element content of viscose fiber based C/C composites were determined by atomic fluorescence analyzer and inductively coupled plasma atomic emission spectrometry. The results reveal that there are few biological toxic elements in the viscose fiber based C/C composites and it can satisfy the constituent demands of surgical implants.

Key words: viscose carbon fiber based C/C composites| histological observation| biocompatibility

摘要： The animal experiment of viscose carbon fiber based C/C composites applied in bone defection intramedullary fixation was carried out in New Zealand white rabbits. The histological observation on the 100th day after surgical operation indicated that the experimental animals recovered well and the bone defect area was reconstructed by new bone trabecula. Immunohistochemical observation of leukocyte common antigen and macrophage suggested that intramedullary fixation materials did not induct any chronic toxicity reactions such as inflammatory reactions, macrophage reactions and formation of granulation tissue. The tissue compatibility of this material was excellent. Meanwhile, the impurity element species and the biological toxic element content of viscose fiber based C/C composites were determined by atomic fluorescence analyzer and inductively coupled plasma atomic emission spectrometry. The results reveal that there are few biological toxic elements in the viscose fiber based C/C composites and it can satisfy the constituent demands of surgical implants.

关键词: viscose carbon fiber based C/C composites| histological observation| biocompatibility

CLC Number:

TB 332

CAO Ning1* (曹宁), WANG Wen-bo2 (王文波), DONG Jian-wen2 (董建文). Animal Experiment of Viscose Carbon Fiber Based C/C Composites Applied in Bone Fracture Intramedullary Fixation[J]. Journal of shanghai Jiaotong University (Science), 2012, 17(5): 537-540.

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Animal Experiment of Viscose Carbon Fiber Based C/C Composites Applied in Bone Fracture Intramedullary Fixation

Animal Experiment of Viscose Carbon Fiber Based C/C Composites Applied in Bone Fracture Intramedullary Fixation

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