Abstract: A new concept in the system of gastric cancer prewarning and early theranostics based on nanotechnology is summarized, including a series of research and the achievements under the guidance of the concept. The survey covers three aspects: we screened and identified some gastric cancer biomarkers associated with prewarning, early diagnosis and staging of gastric cancer; we developed a series of multi-functional nanoprobes integrated with the diagnosis and treatment of gastric cancer, which can realize simultaneous theranostics and monitoring in the gastric cancer mice models; we promoted clinical translation of lateral flow test chips and quantitative testing instruments, and we developed nanoprobes for identifying the operation boundary of gastric cancer and tracing metastasis lymph nodes. The research findings are conducted to perfect the system, and to boost clinical applications.

Key words: gastric cancer, prewarning, early theranostics system, nanotechnology, gene chips, nanoprobes, sensors