Journal of Shanghai Jiao Tong University ›› 2016, Vol. 50 ›› Issue (03): 478-482.

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Relationship Between Dyslipidemia and Proteinuria in Patients with Diabetic Nephropathy

LI Junhui,CHENG Dongsheng,WANG Feng,FEI Yang,XUE Qin,WANG Niansong   

  1. (School of Medicine, Soochow University, Suzhou 215006, Jiangsu, China; Department of Nephrology, Sixth People’s Hospital Affliated to Shanghai Jiaotong University, Shanghai 200233, China)
  • Received:2015-04-15 Online:2016-03-28 Published:2016-03-28

Abstract: Abstract: The relationship between 24 h urine protein excretion with dyslipidemia in diabetic nephropathy(DN) patients was evaluated. A total of 122 DN patients (49 females and 73 males) with an average age of (62.26±12.67) were included in this study. 24hour urine were collected for 24h protein(24 h pro) measurement and blood samples were taken as lipid parammeters. According to 24 h pro assays, subjects were divided into nephrotic group and nonnephrotic group. Lipid profiles and correlation analysis were compared between the two groups. It is found that the levels of total cholesterol(TC), non high density lipoprotein (NHDL), lipoprotein (a) [Lp(a)], and apolipoprotein B (ApoB) were much higher in nephrotic group compared with nonnephrotic one (P<0.05). In correlation analysis, TC, NHDL, ApoB and ApoE were found to be related to 24 h urine protein and HbA1C (P<0.01) respectively and Lpa was related to 24 h pro and eGFR. LDLC and TG were independently associated with HbA1C (P<0.01) while ApoA1 was only associated with 24 h pro (P<0.05). In each group classified according to quartiles of lipid profile, it is found that the proportion of patients with >3.5 g/24 h urine protein excretion grew progressively with the increase in TC, NHDLC, TG, ApoA1, ApoB,Lpa and ApoE (P<0.05) while LDLC and HDLC had no statistical differences (P>0.05). Conclusion: In patients with diabetic nephropathy, an obvious dyslipidemia was observed with increase of 24 h urine protein excretion, especially in those with nephrotic syndrome who mainly present with the an elevation in TC, NHDL, Lpa and ApoB. Since dyslipidemia could aggravate the progress of kidney disease, an effective control of lipid profile is likely to improve the prognosis.

Key words: Key words: diabetic nephropathy, dyslipidemia, nonhigh density lipoprotein, lipoprotein (a), urine protein

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