Abstract: Abstract： The relationship between 24 h urine protein excretion with dyslipidemia in diabetic nephropathy(DN) patients was evaluated. A total of 122 DN patients (49 females and 73 males) with an average age of (62.26±12.67) were included in this study. 24hour urine were collected for 24h protein(24 h pro) measurement and blood samples were taken as lipid parammeters. According to 24 h pro assays, subjects were divided into nephrotic group and nonnephrotic group. Lipid profiles and correlation analysis were compared between the two groups. It is found that the levels of total cholesterol(TC), non high density lipoprotein (NHDL), lipoprotein (a) ［Lp(a)］, and apolipoprotein B (ApoB) were much higher in nephrotic group compared with nonnephrotic one (P<0.05). In correlation analysis, TC, NHDL, ApoB and ApoE were found to be related to 24 h urine protein and HbA1C (P<0.01) respectively and Lpa was related to 24 h pro and eGFR. LDLC and TG were independently associated with HbA1C (P<0.01) while ApoA1 was only associated with 24 h pro (P<0.05). In each group classified according to quartiles of lipid profile, it is found that the proportion of patients with >3.5 g/24 h urine protein excretion grew progressively with the increase in TC, NHDLC, TG, ApoA1, ApoB,Lpa and ApoE (P<0.05) while LDLC and HDLC had no statistical differences (P>0.05). Conclusion: In patients with diabetic nephropathy, an obvious dyslipidemia was observed with increase of 24 h urine protein excretion, especially in those with nephrotic syndrome who mainly present with the an elevation in TC, NHDL, Lpa and ApoB. Since dyslipidemia could aggravate the progress of kidney disease, an effective control of lipid profile is likely to improve the prognosis.

Key words: Key words： diabetic nephropathy, dyslipidemia, nonhigh density lipoprotein, lipoprotein (a), urine protein