Journal of Shanghai Jiao Tong University ›› 2021, Vol. 55 ›› Issue (Sup.1): 41-43.doi: 10.16183/j.cnki.jsjtu.2021.S1.037

Special Issue: 上海交通大学建校125周年科学问题专辑

• Medical Science • Previous Articles     Next Articles

Production and Glycan Evolution of Therapeutic Glycoproteins


  1. Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China
  • Received:2021-02-03 Online:2021-03-28 Published:2021-04-09

Abstract: Therapeutic glycoproteins show the advantages of specificity, outstanding curative effect, and good safety in many diseases. Glycosylation is an important factor affecting molecular stability, immunogenicity, and pharmacokinetic profiles. By means of glycoengineering strategies, researches on the evolution of glycan on therapeutic glycoproteins have deepened. This paper briefly describes the production and modification of recombinant glycoproteins in vivo or vitro, and indicates that the production of homogeneous glycoprotein is the prerequisite for studying the effect of glycan on therapeutic glycoprotein properties.

Key words: therapeutic glycoprotein; homogeneous glycan

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