Design and Fabrication of Drug-Loaded Metal Microneedle

Journal of Shanghai Jiaotong University ›› 2012, Vol. 46 ›› Issue (09): 1428-1430.

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Design and Fabrication of Drug-Loaded Metal Microneedle

CAO Yu-Tian, ZHU Jun, CAO Ying, LI Yi-Gui, CHEN Xiang, CHEN Di

(Research Institute of Micro/Nanometer Science and Technology, National Key Laboratory of Nano/Micro Fabrication Technology, Key Laboratory for Thin Film and Micro Fabrication ofMinistry of Education, Shanghai Jiaotong University, Shanghai 200030, China)

Received:2011-10-21 Online:2012-09-28 Published:2012-09-28

Abstract

Abstract: A novel structure design of coating out-of-plane microneedle was presented. With the combined adoption of anisotropic etching of silicon and photolithography of SU-8 photoresist, the mould of coating microneedle was prepared. The PDMS positive and negative structure was made by PDMS casting. Ni microneedle was prepared on the base of PDMS negative structure with low electric current electroforming. The fracture strength of the Ni microneedle is 366 MPa which is far higher than 3.183 MPa，the required insertion pressure of human skin. The design improves the drug-loaded ability of the microneedle.

Key words: microneedle, photoresist, anisotropic etching, fracture strength

CAO Yu-Tian, ZHU Jun, CAO Ying, LI Yi-Gui, CHEN Xiang, CHEN Di. Design and Fabrication of Drug-Loaded Metal Microneedle [J]. Journal of Shanghai Jiaotong University, 2012, 46(09): 1428-1430.

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[1]	LU Qi，CHEN Xiang，XIAO Lijun，CHEN Di . Design and Manufacture of An Integrated Micro Flow Sensor with SU-8 Channel [J]. Journal of Shanghai Jiaotong University, 2010, 44(11): 1519-1523.
[2]	JIANG Hongmin,ZHU Jun,CAO Ying,CHEN Xiang,CHEN Di . Application of Inclined and Rotating UV Lithography in Preparation of Microneedles [J]. Journal of Shanghai Jiaotong University, 2010, 44(08): 1100-1102.

Design and Fabrication of Drug-Loaded Metal Microneedle

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