Abstract: The degradation behavior of ceftazidime in water was studied using highperformance liquid chromatography. Experiments were conducted under conditions with different temperature, pH, water samples, sterile & nonsterile and light. The results show that the standard degradation kinetic process can be described by the firstorder reaction (halflife = 1.83 d). Increasing temperature (from 5 to 45 ℃) or pH (5 to 9) can accelerate degradation of ceftazidime (38.27 times for temperature and 13.03 times for pH, respectively). The degradation rate of ceftazidime in wastewater is relatively high among the tested samples. This study provides some fundamental data for assessing the behavior and ecological risk of ceftazidime in aquatic environment.