Abstract: The occurrences and removals of five cephalosporin antibiotics in two local Wastewater Treatment Plants (MHWWTP and XZWWTP) at different seasons were investigated by applying the analytical method of Solid Phase ExtractionHigh Performance Liquid ChromatographyUltraviolet Detector (SPEHPLCUVD). The preliminary risk assessment of discharge wastewater to the receiving water was performed. The results showed that all the five cephalosporin antibiotics were identified in the influent and effluent of WWTPs with the range (average values) of 1.122.75 μg/L and 0.011.32 μg/L, respectively. The comparison of seasonal data in MHWWTP showed the analyte concentrations in samples collected in July were relatively lower than those in samples collected in other seasons. This might be due to the usage fluctuation of cephalosporin antibiotics and the enhanced degradation by high temperature. In addition, it was indicated that higher removal efficiencies of cephalosporin antibiotics were obtained in the treatment process of oxidation ditch rather than that of A2/O. According to the daily mass flow of five cephalosporin antibiotics in effluent samples, it was noted that different cephalosporin antibiotics had different discharge load in varied seasons and might potentially pose dissimilar ecological and environmental risks to the receiving water.