Abstract: A new method of blind dereverberation of single channel was proposed to solve the existing problem in speech signal processing. Firstly, segmentation of speech signal with variant length is carried on the sampled speech signal, and the complex cepstrum is applied to the valid segments. Then, the preestimation of the room impulse response is obtained by this method, and so is the inversefilter solution. At last, blind deconvolution is used by taking the inversefilter as the initial parameter of the algorithm. The simulations and experiments show its validity of the proposed method.