Abstract: The blood-brain barrier (BBB) protects the brain against exogenous harmful compounds, but it also impedes the delivery of diagnostic and therapeutic agents to the brain, thereby hindering progress of new drug development for central nervous system (CNS) disorders. There are natural substances that can traverse the BBB emerged in organisms. A comprehensive study on their biological interactions with BBB will provide critical insights into the design and development of bioinspired brain-targeted delivery systems. In this paper, a series of brain delivery strategies were discussed with an emphasis on the bioinspired nano-delivery system which has great potential for clinical applications. The research findings could be applied to facilitate the clinical translation of brain-targeted diagnosis and treatment products.

Key words: blood-brain barrier (BBB); biomimetic nano-delivery system; central nervous system (CNS) disorders; neutrophil; human ferritin nanoparticle