Abstract: As the earliest element in the universe and the most abundant one in living organisms, hydrogen shows a wide range of positive impact on biological systems, including physiology regulation, selective anti-oxidation, etc. At present, hydrogen has gradually found applications in medical science and agriculture, which leads to the establishment of “hydrogen biology”. Exploring the mechanism of how hydrogen operates in living organisms and accurately understanding its role in life will provide an alternative and promising approach to overcoming many critical challenges faced by the living systems.

Key words: hydrogen biology; mechanism; hydrogen medicine; hydrogen agriculture