上海交通大学学报

上海交通大学学报 ›› 2021, Vol. 55 ›› Issue (Sup.1): 60-61.doi: 10.16183/j.cnki.jsjtu.2021.S1.045

所属专题： 上海交通大学建校125周年科学问题专辑

• 医学科学 • 上一篇    下一篇

如何建立器官再生的血管网络？

张文杰   

  1. 上海交通大学医学院附属第九人民医院 口腔修复科， 上海 200011
  • 收稿日期:2021-02-03 出版日期:2021-03-28 发布日期:2021-04-09
  • 通讯作者: 张文杰（1985-），男，山东省临沂市人，副研究员，博士生导师，从事口腔组织再生研究. 电话（Tel.）：021-53315396；E-mail：zhangwenjie586@126.com.
  • 基金资助:
    国家自然科学基金（82022015，32071361），上海市自然科学基金（20QA1405700）资助项目

How to Build the Vascular Network for Organ Regeneration？

ZHANG Wenjie   

  1. Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
  • Received:2021-02-03 Online:2021-03-28 Published:2021-04-09

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摘要： 干细胞与组织工程技术的发展为大块组织缺损修复和器官替代提供了新思路，但人体器官血管网络精细复杂，是限制器官再生和移植的主要瓶颈问题.类器官体外培养尺寸无法突破同样受到无法形成血管系统的限制.对此，提出同步构建功能化血管网络的设想，为维系干细胞存活和实现器官再生打好基础.

关键词: 器官再生；血管化；干细胞

Abstract: Development in the stem cells and tissue engineering technology provides novel ideas both for large tissue defect treatment and organ replacement. However, the vascular network in human organs is delicate and complex, which is hard to be manufactured and has become the main bottleneck in organ regeneration and transplantation. In addition, the inability to form a vascular system also restricts the size of organoids cultured in vitro from breaking through. Therefore, an idea of building synchronized functional vascular network was proposed to lay a good foundation for maintaining stem cell survival and developing organ regeneration.

Key words: organ regeneration; vascularization; stem cell

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