上海交通大学学报

上海交通大学学报 ›› 2021, Vol. 55 ›› Issue (Sup.1): 58-59.doi: 10.16183/j.cnki.jsjtu.2021.S1.044

所属专题： 上海交通大学建校125周年科学问题专辑

• 医学科学 • 上一篇    下一篇

Aβ级联假说或tau蛋白假说，哪个更正确？

马步勇   

  1. 上海交通大学 药学院；细胞工程及抗体药物教育部工程研究中心， 上海 200240
  • 收稿日期:2021-02-03 出版日期:2021-03-28 发布日期:2021-04-09
  • 通讯作者: 马步勇(1963-)，男，安徽省阜阳市人，教授，博士生导师，从事计算化学与计算生物学研究.E-mail：mabuyong@sjtu.edu.cn.

Amyloid Hypothesis or Tau Hypothesis, Which Is Right?

MA Buyong   

  1. School of Pharmacy; Engineering Research Center of Cell and Therapeutic Antibody of the Ministry of Education, Shanghai Jiao Tong University, Shanghai 200240, China
  • Received:2021-02-03 Online:2021-03-28 Published:2021-04-09

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摘要： 介绍了淀粉样变性、朊蛋白和阿尔茨海默病的Aβ和tau蛋白.指出Aβ级联假说或tau蛋白假说反映的是一个硬币的两面，揭示的是淀粉样变性共性中阿尔茨海默病的特性，其寡聚体结构的解析具有重要的学术和应用意义.

关键词: 淀粉样变性；阿尔茨海默病；淀粉样β肽；tau蛋白；寡聚体

Abstract: This paper introduces amyloidosis, prion, and Aβ/tau proteins in Alzheimer’s disease. It points out that the amyloid hypothesis and the tau hypothesis are two sides of a coin, which reflect the specialty of Alzheimer’s disease among common features of amyloidosis. The elucidations of oligomer structures in Aβ peptide and tau protein have significances in understanding amyloidosis and fighting against Alzheimer’s disease or general amyloidosis.

Key words: amylodosis; Alzheimer’s disease; Aβ peptide; tau protein; oligomer

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