上海交通大学学报

上海交通大学学报 ›› 2021, Vol. 55 ›› Issue (Sup.1): 55-57.doi: 10.16183/j.cnki.jsjtu.2021.S1.043

所属专题： 上海交通大学建校125周年科学问题专辑

• 医学科学 • 上一篇    下一篇

精准治疗有希望治愈肿瘤吗？

张苏江，陈赛娟   

  1. 上海交通大学医学院附属瑞金医院 国家转化医学中心, 上海 200025
  • 收稿日期:2021-02-05 出版日期:2021-03-28 发布日期:2021-04-09
  • 通讯作者: 陈赛娟，女，中国工程院院士.E-mail：sjchen@stn.sh.cn.
  • 作者简介:张苏江(1972-)，男，江苏省扬州市人，主任医师，主要从事各种急慢性白血病的诊治.

Could Precision Therapy Cure Tumor?

ZHANG Sujiang,CHEN Saijuan   

  1. National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Received:2021-02-05 Online:2021-03-28 Published:2021-04-09

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摘要： 以肿瘤靶向药物为代表的精准治疗正在给肿瘤治疗带来变革性的突破.急性早幼粒细胞白血病(APL)以往属于高致死性恶性血液肿瘤，如今，基于分子机制的精准诊断和精准治疗使APL成为第一个可被基本治愈的急性髓系白血病.近年来，前瞻性的全国多中心随机对照临床试验的优化治疗、 诊断分层体系优化、APL致癌蛋白PML-RARa协同靶向治疗调控图谱的阐明，为高危患者提供更多的治愈机遇.协同靶向精准治疗APL的思路将进一步拓展至其他类型白血病，甚至实体瘤.

关键词: 肿瘤；精准治疗；急性早幼粒细胞白血病

Abstract: Precision therapy, represented by cancer targeted drugs, is bringing revolutionary breakthroughs to treatment. Acute promyelocytic leukemia (APL), formerly defined as a highly lethal hematological malignancy, can now be mostly cured by precision diagnosis and treatment based on clarification of molecular pathogenesis. Recently, prospective multicenter randomized controlled clinical trial, precise scoring system, PML-RARa directed target atlas regulated by synergistic treatment can further help us overcome the remaining obstacles of high risk APL cure. This concept could extend to other types of leukemia or solid tumors.

Key words: tumor; precision therapy; acute promyelocytic leukemia

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