J Shanghai Jiaotong Univ Sci

Journal of Shanghai Jiaotong University(Science) >

2024 , Vol. 29 >Issue 6: 979 - 994

DOI: https://doi.org/10.1007/s12204-022-2454-1

Medicine-Engineering Interdisciplinary

Short-Term Effects of Ambient Air Pollutants on Outpatient Visits for Childhood Allergic Diseases in Shanghai, China

  • HU Yi1 (户宜) ,
  • GU Jianlei1 (顾坚磊) ,
  • WU Dan1 (吴丹) ,
  • WANG Xiaolei2 (王晓雷) ,
  • LU Hui ¨ 1 ,
  • 2 (吕晖) ,
  • YU Guangjun1 ,
  • 3? (于广军)
Expand
  • （1. Center for Biomedical Informatics, Shanghai Children’s Hospital, Shanghai Jiao Tong University School of Medicine,Shanghai 200040, China; 2. SJTU-Yale Joint Center for Biostatistics and Data Science, Department of Bioinformatics and Biostatistics, Shanghai Jiao Tong University, Shanghai 200240, China; 3. Shanghai Engineering Research Center for Big Data in Pediatric Precision Medicine, Shanghai 200040, China)

Accepted date: 2021-08-04

  Online published: 2024-11-28

Fold

Abstract

This study aims to investigate the short-term effects of ambient air pollutants on outpatient visits for childhood allergic diseases. Daily data on ambient air pollutants (NO2, SO2, CO and PM2.5) and outpatient visits for childhood allergic diseases (asthma, atopic dermatitis and allergic rhinitis) were obtained in Shanghai, China from 2013 to 2014. The effects of ambient air pollutants were estimated for total outpatient visits for childhood allergic diseases, gender and age stratification and disease classification by using distributed lag non-linear model (DLNM). We found positive associations between short-term exposure to air pollutants and childhood allergic diseases. Girls and children aged  7 years old were more likely to be sensitive to ambient air pollutants. NO2 and SO2 showed stronger effects on asthma and atopic dermatitis, respectively. This study provides evidence that short-term exposure to ambient air pollutants can increase the risk of childhood allergic diseases.

Key words： childhood allergic diseases, ambient air pollutant, nitrogen dioxide (NO2), sulfur dioxide (SO2), particulate matter <; 2.5 μm in diameter (PM2.5)

Cite this article

HU Yi1 (户宜), GU Jianlei1 (顾坚磊), WU Dan1 (吴丹), WANG Xiaolei2 (王晓雷), LU Hui ¨ 1, 2 (吕晖), YU Guangjun1, 3? (于广军). Short-Term Effects of Ambient Air Pollutants on Outpatient Visits for Childhood Allergic Diseases in Shanghai, China[J]. Journal of Shanghai Jiaotong University(Science), 2024, 29(6): 979-994. DOI: 10.1007/s12204-022-2454-1

References

[1] LU C, NORBACK D, LI Y G, et al. Early-life exposure to air pollution and childhood allergic diseases: An update on the link and its implications [J]. Expert Review of Clinical Immunology, 2020, 16(8): 813-827.
[2] TOSKALA E, KENNEDY D W. Asthma risk factors [J]. International Forum of Allergy & Rhinology, 2015, 5(Suppl 1): S11-S16.
[3] ASHER M I, MONTEFORT S, BJORKST EN B, et al.Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys [J]. Lancet, 2006, 368(9537): 733-743.
[4] SEREBRISKY D, WIZNIA A. Pediatric asthma: A global epidemic [J]. Annals of Global Health, 2019, 85(1): 6.
[5] National Cooperation Group on Childhood Asthma. Comparative analysis of the state of asthma prevalence in children from two nation-wide surveys in 1990 and 2000 year [J]. Chinese Journal of Tuberculosis and Respiratory Diseases, 2004, 27(2): 112-116 (in Chinese).
[6] National Cooperation Group on Childhood Asthma. Third nationwide survey of childhood asthma in urban areas of China [J]. Chinese Journal of Pediatrics, 2013, 51(10): 729-735 (in Chinese).
[7] ZHANG Y, ZHANG L. Increasing prevalence of allergic rhinitis in China [J]. Allergy, Asthma & Immunology Research, 2019, 11(2): 156-169.
[8] GUO Y F, LI P, TANG J P, et al. Prevalence of atopic dermatitis in Chinese children aged 1-7 ys [J]. Scientific Reports, 2016, 6: 29751.
[9] LONDON S J. Gene-air pollution interactions in asthma [J]. Proceedings of the American Thoracic Society, 2007, 4(3): 217-220.
[10] KIM B J, HONG S J. Ambient air pollution and allergic diseases in children [J]. Korean Journal of Pediatrics, 2012, 55(6): 185-192.
[11] BOWATTE G, LODGE C, LOWE A J, et al. The influence of childhood traffic-related air pollution exposure on asthma, allergy and sensitization: A systematic review and a meta-analysis of birth cohort studies [J]. Allergy, 2015, 70(3): 245-256.
[12] TENG B, ZHANG X L, YI C H, et al. The association between ambient air pollution and allergic rhinitis:Further epidemiological evidence from Changchun, Northeastern China [J]. International Journal of Environmental Research and Public Health, 2017, 14(3): 226.
[13] HU Y B, XU Z W, JIANG F, et al. Relative impact of meteorological factors and air pollutants on childhood allergic diseases in Shanghai, China [J]. Science of the Total Environment, 2020, 706: 135975.
[14] ANENBERG S C, HENZE D K, TINNEY V, et al. Estimates of the global burden of ambient PM2.5, ozone, and NO2 on asthma incidence and emergency room visits [J]. Environmental Health Perspectives, 2018, 126(10): 107004.
[15] KHREIS H, KELLY C, TATE J, et al. Exposure to traffic-related air pollution and risk of development of childhood asthma: A systematic review and metaanalysis [J]. Environment International, 2017, 100: 1- 31.
[16] LIU W, CAI J, FU Q Y, et al. Associations of ambient air pollutants with airway and allergic symptoms in 13, 335 preschoolers in Shanghai, China [J]. Chemosphere, 2020, 252: 126600.
[17] BAEK J O, CHO J, ROH J Y. Associations between ambient air pollution and medical care visits for atopic dermatitis [J]. Environmental Research, 2021, 195: 110153.
[18] LIU L J, LIU C, CHEN R J, et al. Associations of short-term exposure to air pollution and emergency department visits for pediatric asthma in Shanghai, China [J]. Chemosphere, 2021, 263: 127856.
[19] GASPARRINI A, ARMSTRONG B, KENWARD M G. Distributed lag non-linear models [J]. Statistics in Medicine, 2010, 29(21): 2224-2234.
[20] ZHANG Y W, NI H, BAI L J, et al. The short-term association between air pollution and childhood asthma hospital admissions in urban areas of Hefei City in China: A time-series study [J]. Environmental Research, 2019, 169: 510-516.
[21] DING L, ZHU D J, PENG D H, et al. Air pollution and asthma attacks in children: A case-crossover analysis in the city of Chongqing, China [J]. Environmental Pollution, 2017, 220: 348-353.
[22] SAMOLI E, NASTOS P T, PALIATSOS A G, et al. Acute effects of air pollution on pediatric asthma exacerbation: Evidence of association and effect modification [J]. Environmental Research, 2011, 111(3): 418- 424.
[23] MA Y X, YU Z A, JIAO H R, et al. Short-term effect of PM2.5 on pediatric asthma incidence in Shanghai, China [J]. Environmental Science and Pollution Research, 2019, 26(27): 27832-27841.
[24] CASTNER J, GUO L F, YIN Y. Ambient air pollution and emergency department visits for asthma in Erie County, New York 2007-2012 [J]. International Archives of Occupational and Environmental Health, 2018, 91(2): 205-214.
[25] RODR′IGUEZ-VILLAMIZAR L A, ROJAS-ROA N Y, FERNANDEZ-NINO J A. Short-term joint effects of ambient air pollutants on emergency department visits for respiratory and circulatory diseases in Colombia, 2011-2014 [J]. Environmental Pollution, 2019, 248: 380-387.
[26] GUO X J, LI Z Y, LING W J, et al. Epidemiology of childhood asthma in mainland China (1988-2014): A meta-analysis [J]. Allergy and Asthma Proceedings, 2018, 39(3): 15-29.
[27] HUANG S K, ZHANG Q L, QIU Z M, et al. Mechanistic impact of outdoor air pollution on asthma and allergic diseases [J]. Journal of Thoracic Disease, 2015, 7(1): 23-33.
[28] MURRISON L B, BRANDT E B, MYERS J B, et al. Environmental exposures and mechanisms in allergy and asthma development [J]. The Journal of Clinical Investigation, 2019, 129(4): 1504-1515.
[29] KRAVITZ-WIRTZ N, TEIXEIRA S, HAJAT A, et al. Early-life air pollution exposure, neighborhood poverty, and childhood asthma in the United States, 1990-2014 [J]. International Journal of Environmental Research and Public Health, 2018, 15(6): 1114.
[30] LIU W, CAI J, HUANG C, et al. Associations of gestational and early life exposures to ambient air pollution with childhood atopic eczema in Shanghai, China [J]. Science of the Total Environment, 2016, 572: 34-42.
[31] ZOU Q Y, SHEN Y, KE X, et al. Exposure to air pollution and risk of prevalence of childhood allergic rhinitis: A meta-analysis [J]. International Journal of Pediatric Otorhinolaryngology, 2018, 112: 82-90.
[32] GLENCROSS D A, HO T R, CAMINA N, et al. Air pollution and its effects on the immune system [J]. Free Radical Biology and Medicine, 2020, 151: 56-68.
[33] BONTINCK A, MAES T, JOOS G. Asthma and air pollution: Recent insights in pathogenesis and clinical implications [J]. Current Opinion in Pulmonary Medicine, 2020, 26(1): 10-19.
[34] HONDA A, FUKUSHIMA W, OISHI M, et al. Effects of components of PM2.5 collected in Japan on the respiratory and immune systems [J]. International Journal of Toxicology, 2017, 36(2): 153-164.
[35] LI X J, HUANG L Q, WANG N, et al. Sulfur dioxide exposure enhances Th2 inflammatory responses via activating STAT6 pathway in asthmatic mice [J]. Toxicology Letters, 2018, 285: 43-50.
[36] GUO Z, ZHAO R, ZHANG R, et al. Effect of PM2.5 on inflammatory factors and pathology of nasal mucosa in a rat model of allergic rhinitis [J]. Chinese Journal of Otorhinolaryngology Head and Neck Surgery, 2019, 54(5): 362-366 (in Chinese).
[37] ESPOSITO S, TENCONI R, LELII M, et al. Possible molecular mechanisms linking air pollution and asthma in children [J]. BMC Pulmonary Medicine, 2014, 14: 31.
[38] HAVET A, LI Z, ZERIMECH F, et al. Does the oxidative stress play a role in the associations between outdoor air pollution and persistent asthma in adults? Findings from the EGEA study [J]. Environmental Health, 2019, 18(1): 90.
[39] QI C C, XU C J, KOPPELMAN G H. The role of epigenetics in the development of childhood asthma [J].Expert Review of Clinical Immunology, 2019, 15(12): 1287-1302.
[40] SOMINENI H K, ZHANG X, BIAGINI MYERS J M, et al. Ten-eleven translocation 1 (TET1) methylation is associated with childhood asthma and traffic-related air pollution [J]. Journal of Allergy and Clinical Immunology, 2016, 137(3): 797-805.
[41] ABOLHASANI R, ARAGHI F, TABARY M, et al. The impact of air pollution on skin and related disorders: A comprehensive review [J]. Dermatologic Therapy, 2021, 34(2): e14840.
[42] USHIO H, NOHARA K, FUJIMAKI H. Effect of environmental pollutants on the production of proinflammatory cytokines by normal human dermal keratinocytes [J]. Toxicology Letters, 1999, 105(1): 17-24.
[43] HASSOUN Y, JAMES C, BERNSTEIN D I. The effects of air pollution on the development of atopic disease [J]. Clinical Reviews in Allergy & Immunology, 2019, 57(3): 403-414.
[44] HUSS-MARP J, EBERLEIN-KONIG B, BREUER K,et al. Influence of short-term exposure to airborne Der p 1 and volatile organic compounds on skin barrier function and dermal blood flow in patients with atopic eczema and healthy individuals [J]. Clinical & Experimental Allergy, 2006, 36(3): 338-345.
[45] CLOUGHERTY J E. A growing role for gender analysis in air pollution epidemiology [J]. Environmental Health Perspectives, 2010, 118: 167-176.
[46] PENNINGTON A F, STRICKLAND M J, KLEIN M, et al. Exposure to mobile source air pollution in earlylife and childhood asthma incidence: The Kaiser air pollution and pediatric asthma study [J]. Epidemiology, 2018, 29(1): 22-30.
[47] GUO Q, LIANG F C, TIAN L, et al. Ambient air pollution and the hospital outpatient visits for eczema and dermatitis in Beijing: A time-stratified case-crossover analysis [J]. Environmental Science Processes & Impacts, 2019, 21(1): 163-173.
[48] MOHRENSCHLAGER M, SCH AFER T, HUSS- MARP J, et al. The course of eczema in children aged 5-7 years and its relation to atopy: Differences between boys and girls [J]. British Journal of Dermatology, 2006, 154(3): 505-513.
[49] SUWANWAIPHATTHANA W, RUANGDEJ K, TURNER-HENSON A. Outdoor air pollution and children’s health [J]. Pediatric Nursing, 2010, 36(1): 25-32.
[50] NANDASENA S, WICKREMASINGHE A R, SATHIAKUMAR N. Indoor air pollution and respiratory health of children in the developing world [J]. World Journal of Clinical Pediatrics, 2013, 2(2): 6-15.
[51] BATESON T F, SCHWARTZ J. Children’s response to air pollutants [J]. Journal of Toxicology and Environmental Health, Part A, 2007, 71(3): 238-243.
[52] BRENNER H, LOOMIS D. Varied forms of bias due to nondifferential error in measuring exposure [J]. Epidemiology, 1994, 5(5): 510-517.
[53] LUO Y X, LI H B, HUANG F F, et al. The cold effect of ambient temperature on ischemic and hemorrhagic stroke hospital admissions: A large database study in Beijing, China between years 2013 and 2014—Utilizing a distributed lag non-linear analysis [J]. Environmental Pollution, 2018, 232: 90-96.
[54] HU Y B, CHENG J, JIANG F, et al. Season-stratified effects of meteorological factors on childhood asthma in Shanghai, China [J]. Environmental Research, 2020, 191: 110115.
Options

/

〈 〉