By combining cryogenic cryotherapy and high-temperature radiofrequency therapy, multimodal abla-
tion generates a rapidly changing temperature field in tissue by heating after pre-freezing. This method completely
breaks tumour cells and releases a large amount of active antigen. Compared with the traditional single modal-
ity, the thermal physical ablation method has been shown to have a greater therapeutic effect, but it presents
challenges in terms of precise monitoring and rapid control of the temperature during the treatment process.
To solve this problem, we propose a temperature control system design utilizing aspects of probe sensing, real-
time software and hardware signal interfaces, and dynamic compensation control strategies to accurately monitor
the temperature changes during multimodal ablation treatment. The results show that the design system has
millisecond-level high-speed control capability, an accuracy of 0.5 ?C, and the dynamic response time is less than
0.1 s. Furthermore, the temperature fluctuation in in vivo e x p e r i m e n t s i s l e s s t h a n 0 . 5 ?C.
ZOU Ke (邹 柯), ZOU Jincheng (邹金成), WANG Yifei (王逸飞), ZHANG Aili ∗ (张爱丽)
. Design of Real-Time Temperature Monitoring and Control System for Multimodal Ablation[J]. Journal of Shanghai Jiaotong University(Science), 2022
, 27(4)
: 535
-542
.
DOI: 10.1007/s12204-022-2432-7
[1] XU L X, ZHANG A L, LIU P, et al. Energy-based diagnostic and treatment techniques: Possible applications for early detection and treatment of breast cancer [J].IEEE Engineering in Medicine and Biology Magazine,2008, 27(5): 72-77.
[2] SUN J Q, ZHANG A L, XU L X. Evaluation of alternate cooling and heating for tumor treatment [J]. International Journal of Heat and Mass Transfer, 2008,51(23/24): 5478-5485.
[3] SHEN Y Y, ZHANG A L. Study of alternate cooling and heating treatment induced tumor microvasculature injury [J]. Chinese Science Bulletin, 2010, 55(2):172-178.
[4] BAI J F, LIU P, XU L X. Recent advances in thermal treatment techniques and thermally induced immune responses against cancer [J]. IEEE Transactions on Bio-Medical Engineering, 2014, 61(5): 1497-1505.
[5] HE K, JIA S, LOU Y, et al. Cryo-thermal therapy in-duces macrophage polarization for durable anti-tumorimmunity [J]. Cell Death & Disease, 2019, 10(3): 216.
[6] HE K, LIU P, XU L X. The cryo-thermal therapy eradicated melanoma in mice by eliciting CD4(+) T-cell-mediated antitumor memory immune response [J]. Cell Death & Disease, 2017, 8(3): e2703.
[7] ORSI M D, DODD G D, CARDAN R A, et al. Invitro blood-perfused bovine liver model: A physiologic model for evaluation of the performance of radiofre-quency ablation devices [J]. Journal of Vascular and Interventional Radiology, 2011, 22(10): 1478-1483.
[8] ZHANG K W, ZOU J C, HE K, et al. Study of enhanced radiofrequency heating by pre-freezing tis-sue [J]. International Journal of Hyperthermia, 2018,35(1): 79-89.
[9] ZHENG Y, ZHANG K, ZOU J, et al. An noninvasiveand impedance-ignored control strategy of the ablationzone in radiofrequency ablation therapy [C] //201941st Annual International Conference of the IEEE En-gineering in Medicine and Biology Society. Berlin, Ger-many: IEEE, 2019: 5514-5517.
[10] W ANG Y, ZHANG K, ZHANG A, et al. A new modelfor estimation of individual blood flow effect duringmultimode thermal therapy of tumor [C]//2020 42ndAnnual International Conference of the IEEE Engi-neering in Medicine and Biology Society. M o n t r e a l ,Canada: IEEE, 2020: 5053-5056.
[11] ADIBZADEH F, SUMSER K, CURTO S, et al. Sys-tematic review of pre-clinical and clinical devices formagnetic resonance-guided radiofrequency hyperther-mia [J]. International Journal of Hyperthermia, 2020,37(1): 15-27.
[12] JAIN M K, WOLF P D. Temperature-controlled andconstant-power radio-frequency ablation: What affectslesion growth? [J]. IEEE Transactions on Bio-MedicalEngineering, 1999, 46(12): 1405-1412.
[13] ZHANG B, MOSER M A J, ZHANG E M, et al. Anew approach to feedback control of radiofrequencyablation systems for large coagulation zones [J]. Inter-national Journal of Hyperthermia, 2017, 33(4): 367-377.
[14] ISOBE Y, W ATANABE H, YAMAZAKI N, et al.Real-time temperature control system based on thefinite element method for liver radiofrequency abla-tion: Effect of the time interval on control [C]//201335th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. O s a k a ,Japan: IEEE, 2013: 392-396.
[15] MYERSON R J, MOROS E G, DIEDERICH C J,et al. Components of a hyperthermia clinic: Recommendations for staffing, equipment, and treatment monitoring [J]. International Journal of Hyperthermia,2014, 30(1): 1-5.
[16] MANJHI S K, KUMAR R. Performance assessment of K-type, E-type and J-type coaxial thermocouples on the solar light beam for short duration transient measurements [J]. Measurement, 2019, 146: 343-355.
[17] TERZIS A, VON WOLFERSDORF J, WEIGAND B,et al. Thermocouple thermal inertia effects on impingement heat transfer experiments using the transient liquid crystal technique [J]. Measurement Science and Technology, 2012, 23(11): 115303.
[18] CARNOCHAN P, DICKINSON R J, JOINER M C.The practical use of thermocouples for temperature measurement in clinical hyperthermia [J]. International Journal of Hyperthermia, 1986, 2(1): 1-19.
[19] LI Y, ZHANG L. Design of digital K-type thermo-couple temperature transmitter [J]. Applied Mechanicsand Materials, 2013, 433/434/435: 217-220.
[20] CHAKRABORTY D P, BREZOVICH I A. Error sources affecting thermocouple thermometry in RF electromagnetic fields [J]. Journal of MicrowavePower, 1982, 17(1): 17-28.
[21] SA W ADA T, NISHIW AKI N. Response of a thermo-couple to transient temperature changes in a metal to which it is attached [J]. International Journal of Me-chanical Sciences, 1991, 33(7): 551-561.
[22] State Food and Drug Administration. Liquid nitrogencryosurgical equipment: YY 0677—2008 [S]. Beijing:Standards Press of China, 2009 (in Chinese).
[23] State Food and Drug Administration. Radio frequencyablation instrument for liver: YY 0776—2010 [S]. Beijing: Standards Press of China, 2011 (in Chinese).