J Shanghai Jiaotong Univ Sci ›› 2022, Vol. 27 ›› Issue (4): 535-542.doi: 10.1007/s12204-022-2432-7

• Medicine-Engineering Interdisciplinary Research • Previous Articles     Next Articles

Design of Real-Time Temperature Monitoring and Control System for Multimodal Ablation

ZOU Ke (邹 柯), ZOU Jincheng (邹金成), WANG Yifei (王逸飞), ZHANG Aili ∗ (张爱丽)   

  1. (School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China)
  • Received:2020-09-10 Online:2022-07-28 Published:2022-08-11

Abstract: By combining cryogenic cryotherapy and high-temperature radiofrequency therapy, multimodal abla- tion generates a rapidly changing temperature field in tissue by heating after pre-freezing. This method completely breaks tumour cells and releases a large amount of active antigen. Compared with the traditional single modal- ity, the thermal physical ablation method has been shown to have a greater therapeutic effect, but it presents challenges in terms of precise monitoring and rapid control of the temperature during the treatment process. To solve this problem, we propose a temperature control system design utilizing aspects of probe sensing, real- time software and hardware signal interfaces, and dynamic compensation control strategies to accurately monitor the temperature changes during multimodal ablation treatment. The results show that the design system has millisecond-level high-speed control capability, an accuracy of 0.5 ?C, and the dynamic response time is less than 0.1 s. Furthermore, the temperature fluctuation in in vivo e x p e r i m e n t s i s l e s s t h a n 0 . 5 ?C.

Key words: ablation, temperature monitor, system design

CLC Number: