Hydroxyapatite (HA) based materials have been widely used in the field of ligament tissue engineering
in the past decades. It has been previously reported that HA can increase the penetration of marrow-derived
mesenchymal stem cells (MSCs) and MSCs cells into scaffolds due to increased cell differentiation in biological
media. Additionallyit was found that there are much difference between MSCs and anterior cruciate ligament
(ACL) cells. For that reason, we mainly evaluate the biocompatibility of polyethylene terephthalate (PET) silk
scaffold with fibroblasts cells in vitro. We cultured mouse fibroblasts cells on the substrate of PET fiber and
PET-HA scaffold, respectively, and then observed the morphology by using scanning electron microscopy. Our
data indicate that PET-HA scaffold has good biocompatibility with fibroblasts cells and can potentially be useful
in enhancing the fibroblasts cell differentiation and proliferation.
JIANG Jia1 (蒋佳), HAO Wei2 (郝威), LI Yu-zhuo1 (李毓卓), CHEN Jun3* (陈俊),YAO Jin-rong3 (姚晋荣), SHAO Zheng-zhong2 (邵正中), Li Hong1 (李宏),YANG Jian-jun1 (杨建军), CHEN Shi-yi1* (陈世益)
. Biocompatibility Evaluation of Polyethylene Terephthalate Artificial Ligament Coating Hydroxyapatite by Fibroblasts Cells in Vitro[J]. Journal of Shanghai Jiaotong University(Science), 2012
, 17(6)
: 717
-722
.
DOI: 10.1007/s12204-012-1352-3
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