Abstract: In order to design and manufacture a bionic bone scaffold for personalized bone tissue repairing, we give the performance requirements and indicators, and propose a method of establishing a three-dimensional bone scaffold solid model based on the Voronoi architecture. The modeling parameters, number of seed points and scaling factor are found, which can control the model performance. The finite element analysis model of bone scaffold with different number of seed points and scaling factor is set up. By adopting the method of theory analysis, experiment and simulation calculation, the performance parameters of the porosity, the specific surface area and the elastic modulus of 15 sets of bionic bone scaffold model are obtained. The relation between the bone scaffold model parameters and the porosity, the porosity and the specific surface area, the porosity and the equivalent elastic modulus are established. The individual design method of Voronoi bone scaffold is proposed. In the condition of given equivalent elastic modulus and the defected shape of bone, the bone scaffold model with spatial Voronoi architecture which accords with the performance requirements can be designed and produced rapidly, which provides reference for the personalized treatment of bone defecting.

Key words: bone scaffold, Voronoi architecture, personalized design