Gas Exchange Mechanism of High Frequency Ventilation: A Brief Narrative Review and Prospect

doi:10.1007/s12204-022-2424-7

Abstract

Abstract: The high frequency ventilation (HFV) can well support the breathing of respiratory patient with 20%—40% of normal tidal volume. Now as a therapy of rescue ventilation when conversional ventilation failed, the HFV has been applied in the treatments of severe patients with acute respiratory failure (ARF), acute respiratory distress syndrome (ARDS), etc. However, the gas exchange mechanism (GEM) of HFV is still not fully understood by researchers. In this paper, the GEM of HFV is reviewed to track the studies in the last decades and prospect for the next likely studies. And inspired by previous studies, the GEM of HFV is suggested to be continually developed with various hypotheses which will be testified in simulation, experiment and clinic trail. One of the significant measures is to study the GEM of HFV under the cross-disciplinary integration of medicine and engineering. Fully understanding the GEM can theoretically support and expand the applications of HFV, and is helpful in investigating the potential indications and contraindications of HFV.

Key words: mechanical ventilation, high frequency ventilation, gas exchange mechanisms

摘要： 实验表明潮气量仅为正常潮气量20%～40%的高频通气仍能支持呼吸病患者的呼吸。而高频通气作为一种抢救性通气方式，目前常用于急性呼吸衰竭（ARF）、急性呼吸窘迫综合征（ARDS）等重症呼吸病患者的通气治疗。然而，高频通气下气体交换机制至今尚未明确，仍有待于对其进一步研究。本文就近些年来在高频通气下气体交换机制方面的研究进行了综述，并对未来的研究方向进行了展望。基于前人的研究和启发，合理假设、模拟仿真与临床验证将是继续研究高频通气下气体交换机制的重要途经。另外，医工融合，多学科交叉也将是开展高频通气下气体交换机制研究的重要措施。充分揭示高频通气下气体交换机制将为开拓高频通气的应用提供理论上的支持，有助于分析高频通气适应症和并发症。

关键词: 机械通气、高频通气、气体交换机制

CLC Number:

R-1
R 56

YUAN Yueyang1* (袁越阳)，CHEN Yuqing2 (陈宇清)，ZHOU Lil(周理), LIU Wei3 (刘炜)， DAI Zheng3(戴征). Gas Exchange Mechanism of High Frequency Ventilation: A Brief Narrative Review and Prospect[J]. J Shanghai Jiaotong Univ Sci, 2023, 28(4): 546-.

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