上海交通大学学报（英文版） ›› 2014, Vol. 19 ›› Issue (6): 715-717.doi: 10.1007/s12204-014-1572-9

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Real-Time MRI-Controlled Ultrasound Hyperthermia System for Superficial Tumor Treatment

ZHU Meng-yuan (朱梦媛), SHEN Guo-feng* (沈国峰), SU Zhi-qiang (苏志强),CHEN Sheng (陈晟), WU Hao (吴昊)   

  1. (Biomedical Instrument Institute, School of Biomedical Engineering; Med-X Research Institute, Shanghai Jiaotong University, Shanghai 200030, China)
  • 出版日期:2014-12-31 发布日期:2014-12-08
  • 通讯作者: SHEN Guo-feng (沈国峰) E-mail: shenguofeng@sjtu.edu.cn

Real-Time MRI-Controlled Ultrasound Hyperthermia System for Superficial Tumor Treatment

ZHU Meng-yuan (朱梦媛), SHEN Guo-feng* (沈国峰), SU Zhi-qiang (苏志强),CHEN Sheng (陈晟), WU Hao (吴昊)   

  1. (Biomedical Instrument Institute, School of Biomedical Engineering; Med-X Research Institute, Shanghai Jiaotong University, Shanghai 200030, China)
  • Online:2014-12-31 Published:2014-12-08
  • Contact: SHEN Guo-feng (沈国峰) E-mail: shenguofeng@sjtu.edu.cn

摘要： Ultrasound hyperthermia is one of the most important methods in tumor treatment and characterized by non-invasiveness. Magnetic resonance imaging (MRI)-based temperature mapping techniques are safe compared with invasive methods and have been applied to detect temperature changes for a variety of applications. Among these techniques, the proton resonance frequency (PRF) method is relatively advanced. With a temperature measuring experiment, the effectiveness of PRF method has been proved, because the outcome temperature curve and the real temperature curve fit well. After that, an experiment has been conducted on tumors inside rabbit legs and the result indicates that this system is able to performance hyperthermia at targets based on PRF method in temperature mapping.

关键词: ultrasound, hyperthermia, magnetic resonance imaging (MRI), proton resonance frequency (PRF) method

Abstract: Ultrasound hyperthermia is one of the most important methods in tumor treatment and characterized by non-invasiveness. Magnetic resonance imaging (MRI)-based temperature mapping techniques are safe compared with invasive methods and have been applied to detect temperature changes for a variety of applications. Among these techniques, the proton resonance frequency (PRF) method is relatively advanced. With a temperature measuring experiment, the effectiveness of PRF method has been proved, because the outcome temperature curve and the real temperature curve fit well. After that, an experiment has been conducted on tumors inside rabbit legs and the result indicates that this system is able to performance hyperthermia at targets based on PRF method in temperature mapping.

Key words: ultrasound, hyperthermia, magnetic resonance imaging (MRI), proton resonance frequency (PRF) method

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