Vibration Characteristics of Cochlear Basilar Membrane in Guinea Pig

Abstract

Abstract: Abstract： In order to study the auditory mechanism of the guniea pig cochlea, the stapes footplate (SF) and basilar membrane (BM) velocity responses to pure tone were measured using a laser Doppler velocimetry which was able to measure subnanometer vibration from the middle ear and cochlea of the guinea pig. The BM velocity was measured by a reflective microbeads placed onto the scala tympani surface of the BM. The velocity response of the SF was also tested, allowing the calculation of a BM transfer function. The transfer function shows typical tuning features. For a given BM location, the characteristic frequency (CF) of the BM was about 11 kHz. The results show that frequency selectivity and travelling wave exist in the BM.

Key words: Key words： guinea pig, stapes, cochlea, Doppler laser, auditory mechanism； vibration characteristics

CLC Number:

TA Na1,XU Lifu1,RAO Zhushi1,HUANG Xinsheng2,ZHOU Lei2. Vibration Characteristics of Cochlear Basilar Membrane in Guinea Pig [J]. Journal of Shanghai Jiaotong University, 2016, 50(02): 200-203.

References

［1］BEKESY G V. Experiments in hearing ［M］. New York: McGrawHill Book Company, Inc, 1960. ［2］RHRODE W S. Observations of the vibration of the basilar membrane in squirrel monkeys using the Mssbauer technique ［J］. J Acoust Soc Am, 1971, 49(4): 12181231. ［3］SELLICK P, PATUZZI R, JOHNSTONE B. Measurement of basilar membrane motion in the guinea pig using the Mssbauer technique ［J］. J Acoust Soc Am, 1982, 72(1): 131141. ［4］KHANNA S, LEONARD D. Measurement of basilar membrane vibrations and evaluation of the cochlear condition ［J］. Hearing Research, 1986, 23(1): 3753. ［5］ROBLES L, RUGGERO M A, RICH N C. Basilar membrane mechanics at the base of the chinchilla cochlea. I. Inputoutput functions, tuning curves, and response phases ［J］. J Acoust Soc Am, 1986, 80(5):13641374. ［6］NUTTALL A L, DOLAN D F, AVINASH G. Laser Doppler velocimetry of basilar membrane vibration ［J］. Hearing Research, 1991, 51(2): 203214. ［7］COOPER N P, RHODE W S. Basilar membrane mechanics in the hook region of cat and guineapig cochlea ［J］. Hearing Research, 1992, 63(12): 163190. ［8］REN T Y, HE W X, GILLESPIE P G. Measurement of cochlear power gain in the sensitive gerbil ear ［J］. Nature Communications, 2011, 2(1): 17. ［9］KEMP D T. Stimulated acoustic emissions from within the human auditory system ［J］. J Acoust Soc Am, 1978, 64(5): 13861391. ［10］ROBLES L, RUGGERO M A, RICH N C. Twotone distortion on the basilar membrane of the chinchilla cochlea ［J］. J Neurophysiol, 1997, 77(5): 23852399. ［11］NUTTALL A L. Twotone suppression of inner hair cell and basilar membrane responses in the guinea pig ［J］. J Acoust Soc Am, 1993, 93(1): 390400. ［12］ROBLES L, RUGGERO M A, RICH N C. Twotone distortion in the basilar membrane of the cochlea ［J］. Nature, 1991, 349: 413424. ［13］刘迎曦, 李生, 孙秀珍. 人耳传声数值模型［J］. 力学学报, 2008, 40(1): 107113. LIU Yingxi, LI Sheng, SUN Xiuzhen. Numerical modeling of human ear for sound transmission ［J］. Chinese Journal of Theoretical and Applied Mechanics, 2008, 40(1): 107113. ［14］王学林, 周健军, 凌玲,等. 含主动耳蜗的人耳传声有限元模拟［J］. 振动与冲击, 2012, 31(21): 4145. WANG Xuelin, ZHOU Jianjun, LING Ling, et al. FE simulation of sound transmission in human ear with an active cochlea model ［J］. Journal of Vibration and Shock, 2012, 31(21): 4145. ［15］王振龙, 王学林, 胡于进,等. 基于中耳与耳蜗集成有限元模型的耳声传递模拟［J］. 中国生物医学工程学报, 2011, 30(1): 6066. WANG Zhenlong, WANG Xuelin, HU Yujin, et al. FEM simulation of sound transmission based on integrated model of niddle ear and cochlea ［J］. Chinese Journal of Biomedical Engineering, 2011, 30(1): 6066. ［16］姚文娟, 黄新生, 李武, 等. 人工听骨不同接入方式对耳结构动力响应的影响［J］. 医用生物力学, 2010, 25(3): 175181. YAO Wenjuan, HUANG Xinsheng, LI Wu, et al. Effect of different connecting methods for artificial ossicle on dynamic response of ear ［J］. Journal of Medical Biomechanics, 2010, 25(3): 175181. ［17］REN T Y, NUTTALL A L. Basilar membrane vibration in the basal turn of the sensitive gerbil cochlea ［J］. Hearing Research, 2001, 151(1): 4860. ［18］REN T Y. Longitudinal pattern of basilar membrane vibration in the sensitive cochlea ［J］. Proceedings of the National Academy of Sciences USA, 2002, 99(26): 1710117106.