The replacement of artificial joints, the internal fixation of fracture and other orthopedic implants will cause microdamage in the bone around the implant. Microdamage will reduce the bone quality around the implant, and affect the bonding strength within the interface between the implant and the bone, thus influencing the longterm stability of the implant. In this paper, the production and repair of proximal and distal mechanical microdamage after the implantation of screws, as well as variations in the micromechanical property and composition elements of bone tissue were compared during the process of microdamage repair. It is found that with the repair of microdamage, there is a decrease both in the hardness and elastic modulus of local bones. With the final repair of microdamage, the micromechanical properties are restored.