Abstract: A threedimensional finite element model for blast response of double laminated insulating glass curtain wall was constructed. The whole blaststructure coupling model took into account the air layer between glass plies and supporting components representing real blast environment. The whole process from explosive detonation to response of curtain wall was reproduced on a high performance computing platform. The dynamic behavior of glass unit in the curtain wall under blast loading was analyzed and the numerical results were found to be in agreement with the experiment. The results provide reference for the blast resistance design and improvement of curtain wall system.