上海交通大学学报

上海交通大学学报 ›› 2021, Vol. 55 ›› Issue (Sup.1): 51-52.doi: 10.16183/j.cnki.jsjtu.2021.S1.041

所属专题： 上海交通大学建校125周年科学问题专辑

• 医学科学 • 上一篇    下一篇

细胞可塑性如何驱动组织再生与肿瘤发生?

鄢和新   

  1. 上海交通大学医学院附属仁济医院 麻醉科， 上海 200127
  • 收稿日期:2021-02-03 出版日期:2021-03-28 发布日期:2021-04-09
  • 通讯作者: 鄢和新（1973-），男，重庆市人，研究员，博士生导师，从事再生医学与肿瘤研究. 电话（Tel.）：021-31010390-8018；E-mail：hexinyw@163.com.

How Cell Plasticity Drives Regeneration and Tumorigenesis?

YAN Hexin   

  1. Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Received:2021-02-03 Online:2021-03-28 Published:2021-04-09

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摘要： 生物具有显著的可塑性，在组织损伤后可有效再生和重建稳态.当再生信号被异常激活时，该细胞可塑性将促进肿瘤发生.组织再生和肿瘤发生均依赖于组织水平上多形式细胞可塑性的协调整合，因此对其机制的认识有助于损伤修复和肿瘤防治.

关键词: 细胞可塑性；组织再生；肿瘤发生

Abstract: Organism is characterized by a remarkable plasticity, which drives efficient regeneration and restoration of homeostasis after damage. When aberrantly activated, this plasticity contributes to tumor initiation and progression. Both regenerative and tumorigenic processes rely on the coordinated integration at the tissue level of multiple forms of cellular plasticity. Understanding the mechanisms underlying the various forms of cell plasticity may deliver novel strategies for developing regenerative therapies, cancer prevention, and antitumor treatments.

Key words: cell plasticity; regeneration; tumorigenesis

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