上海交通大学学报

上海交通大学学报 ›› 2021, Vol. 55 ›› Issue (Sup.1): 36-38.doi: 10.16183/j.cnki.jsjtu.2021.S1.035

所属专题： 上海交通大学建校125周年科学问题专辑

• 生命科学 • 上一篇    下一篇

TALE靶标基因与农作物广谱持久抗病育种

徐夏萌，徐正银，李颖，阎依超，邹丽芳，陈功友   

  1. 上海交通大学 农业与生物学院，上海 200240
  • 收稿日期:2021-02-10 出版日期:2021-03-28 发布日期:2021-04-09
  • 通讯作者: 陈功友，男，教授，博士生导师，电话（Tel.）：021-34205873；E-mail：gyouchen@sjtu.edu.cn.
  • 作者简介:徐夏萌（1992-），女，河南省三门峡市人，博士生，从事分子植物病理学研究.
  • 基金资助:
    国家自然科学基金重点项目（31830072），国家重点研发计划（2016YFD0100601），重大转基因专项资助（2016ZX08001002）

TALE Targets for Durable Broad-Spectrum Resistance Breeding in Crops

XU Xiameng,XU Zhengyin,LI Ying,YAN Yichao,ZOU Lifang,CHEN Gongyou   

  1. School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China
  • Received:2021-02-10 Online:2021-03-28 Published:2021-04-09

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摘要： 为了揭示黄单胞菌与植物间互作的遗传学基础，培育广谱持久抗病的农作物，本文对这一领域重要研究进展进行了综述.首先指出了黄单胞菌引起植物病害的严重性，分析了黄单胞菌与植物互作如何导致植物抗病或感病，归纳了TALE蛋白主要作用植物的靶标类型，分析了植物基础转录因子TFIIA与NLR类R基因在植物抗病性中的重要性，认为基因编辑TALE蛋白的效应子结合元件(EBE)是未来作物广谱持久抗病育种的重要方向.

关键词: 黄单胞菌, TALE, 抗病基因, 感病基因, 抗病育种

Abstract: To reveal the genetic basis of the interaction between Xanthomonas pathogens and their host plants for breeding durable broad-spectrum resistance crops, the recent important progress in these fields are summarized. The devastation of plant diseases caused by Xanthomonas species is determined by Xanthomonas T3SS effectors, mainly transcription activator-like effectors (TALEs), which target effector-binding element (EBE) sites of either crop resistance (R) or susceptibility (S) genes. Then, the five types of TALE-targets in plants are briefly stated and the importance of plant general transcription factors TFIIA in the activation of NLR-type R genes in plant resistance is stressed. Finally, that gene-editing of EBEs of R or S genes is proposed to be the new strategy for resistance breeding to control crop diseases in the future.

Key words: Xanthomonas, transcription activator-like effector (TALE), resistant gene, susceptible gene, resistance breeding

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