上海交通大学学报

上海交通大学学报 ›› 2021, Vol. 55 ›› Issue (Sup.1): 34-35.doi: 10.16183/j.cnki.jsjtu.2021.S1.034

所属专题： 上海交通大学建校125周年科学问题专辑

• 生命科学 • 上一篇    下一篇

可以利用生物材料学方法对抗耐药细菌吗？

汤亭亭   

  1. 上海交通大学医学院附属第九人民医院 骨科， 上海 200011
  • 收稿日期:2021-02-03 出版日期:2021-03-28 发布日期:2021-04-09
  • 通讯作者: 汤亭亭（1966-），男，安徽省铜陵市人，教授，博士生导师，从事骨科植入物及骨修复材料研究. 电话（Tel.）：021-38452188；E-mail：ttt@sjtu.edu.cn.
  • 基金资助:
    国家自然科学基金（92068205）资助项目

Can Biomaterials Be Used to Combat Antibiotic Resistance of Bacteria?

TANG Tingting   

  1. Department of Orthopaedic Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
  • Received:2021-02-03 Online:2021-03-28 Published:2021-04-09

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摘要： 细菌耐药已成为全球性健康问题.本文提出用抗菌生物材料替代或减少抗生素使用，以有效预防和治疗植入物感染，同时降低耐药菌传播风险.研究策略包括：植入物的表面修饰，增强其自清洁、免疫调节、接触杀菌和释放杀菌等功能；抗菌材料或药物的局部缓释及控释系统研发，实现微环境响应和细胞靶向.

关键词: 细菌耐药；生物材料；植入物；表面修饰；药物释放

Abstract: The antibiotic resistance of bacteria poses a major challenge to global public health. The antibacterial biomaterials were proposed to substitute or reduce the use of antibiotics, thus preventing implant related infections and limiting the propagation of antibiotic resistance. One research strategy is the surface modification of implant to enhance the implant function with self-cleaning, immune-regulating, contact killing, and release killing abilities. The other strategy is the topical delivery of antimicrobials, aiming to realize the sustainable and controllable drug release profile with microenvironment response and cellular targeting.

Key words: antibacterial resistance; biomaterials; implant; surface modification; drug release

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