聚多巴胺对氧化处理后钛合金表面沉积羟基磷灰石的影响

上海交通大学学报（自然版） ›› 2013, Vol. 47 ›› Issue (05): 795-799.

聚多巴胺对氧化处理后钛合金表面沉积羟基磷灰石的影响

刘斌1, 2，冉海琼1，李章朋2，王金清2，杨生荣2

(1.兰州大学口腔医学院, 兰州 730000； 2.中国科学院兰州化学物理研究所固体润滑国家重点实验室, 兰州 730000)

收稿日期:2012-09-03 出版日期:2013-05-28 发布日期:2013-05-28
基金资助:
中国科学院兰州化学物理研究所固体润滑国家重点实验室开放课题（1208）,中国科学院“百人计划”项目

Influence of Polydopamine Coating on Deposition of Hydroxyapaite on Oxidated Titanium Alloy

LIU Bin1,2,RAN Haiqiong1,LI Zhangpeng2,WANG Jinqing2,YANG Shengrong2

(1.School of Stomatology, Lanzhou University, Lanzhou 730000, China; 2.State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics,
Chinese Academy of Sciences, Lanzhou 730000, China)

Received:2012-09-03 Online:2013-05-28 Published:2013-05-28

摘要/Abstract

摘要：

利用阳极氧化法和微弧氧化法分别对医用钛合金表面进行处理，再经聚多巴胺薄膜表面修饰后，利用仿生溶液矿化法制备羟基磷灰石生物活性涂层，并研究聚多巴胺对经不同氧化处理的医用钛合金生物诱导沉积能力的影响；采用场发射扫描电子显微镜、X射线光电子能谱仪和X射线衍射仪对经不同氧化处理及其生物诱导沉积羟基磷灰石涂层的表面形貌、元素组成和相结构进行表征分析.结果表明：阳极氧化和微弧氧化处理后的钛合金表面分别形成了纳米管和微米孔结构；再经聚多巴胺修饰后，可以显著提高羟基磷灰石涂层的生物诱导沉积能力，而且使得羟基磷灰石的排列致密、规则.

关键词: 钛合金；氧化处理； , 聚多巴胺；羟基磷灰石

Abstract:

This work concentrates on the influence of polydopamine (PDA) coating on the bio-induced deposition of hydroxyapaite (HA) on the surface of medical titanium (Ti) alloy pre-treated by anodic oxidation (AO) and microarc oxidation (MAO). Ti alloy was firstly treated by AO and MAO, respectively, and then modified with PDA coating; after that, all samples were immersed into the simulated body fluid (SBF) for depositing HA bioactive coatings. The morphologies, elemental compositions and microstructures were characterized by field-emission scanning electron microscopy, X-ray photoelectron spectroscopy, Xray powder diffraction. Upon AO and MAO treatments, nanotubes and micro holes are formed on Ti alloy, respectively. After being further modified by PDA, the deposition ability of HA on Ti alloy is significantly improved, and the arrangement of HA is relatively compact and ordered.

Key words: Ti alloy, oxidation treatment, polydopamine, hydroxyapaite (HA)

中图分类号:

TG 178

刘斌1, 2，冉海琼1，李章朋2，王金清2，杨生荣2. 聚多巴胺对氧化处理后钛合金表面沉积羟基磷灰石的影响[J]. 上海交通大学学报（自然版）, 2013, 47(05): 795-799.

LIU Bin1,2,RAN Haiqiong1,LI Zhangpeng2,WANG Jinqing2,YANG Shengrong2. Influence of Polydopamine Coating on Deposition of Hydroxyapaite on Oxidated Titanium Alloy[J]. Journal of Shanghai Jiaotong University, 2013, 47(05): 795-799.

参考文献

［1］Liu X Y, Chu P K, Ding C X. Surface modification of titanium, titanium alloys, and related materials for biomedical applications ［J］. Materials Science and Engineering R: Reports, 2004, 47(34): 49121.

［2］谭延斌，王毅，杨庆铭，等. 纳米级羟基磷灰石梯度涂层植入体骨结合的研究［J］. 中国骨与关节损伤杂

志，2005, 20(1): 3840.

TAN Yanbin, WANG Yi, YANG Qingming, et al. Experimental study on the osteointegration of nanophase hydroxyapatite biogradecoated implants ［J］. Chinese Journal of Bone and Joint Injury, 2005, 20(1): 3840.

［3］陈飞，周海，夏杨建. 钛合金微弧氧化陶瓷层性能［J］.稀有金属材料与工程，2008，37(S1)：7073.

CHEN Fei, ZHOU Hai, XIA Yangjian. Tribological behavior of microarc oxidation ceramic coating on Ti6Al4V alloy surfaces ［J］. Rare Metal Materials and Engineering, 2008, 37(S1): 7073.

［4］雷源源，张晓燕，李远会，等. 磷酸盐体系下电压对TC4钛合金微弧氧化陶瓷膜层的影响［J］. 热加工工艺，2012，41（8)：125131.

LEI Yuanyuan, ZHANG Xiaoyan, LI Yuanhui, et al. Effect of voltage on TC4 titanium alloy microarc oxidation ceramic membrane in phosphate setting ［J］. Hot Working Technology, 2012, 41(8): 125131.

［5］刘达理. 钛表面二氧化钛纳米管及其TiTiO2HA复合涂层［D］. 成都：西南交通大学材料科学与工程学院，2009.

［6］Postma A, Yan Y, Wang Y J, et al. Selfpolymerization of dopamine as a versatile and robust technique to prepare polymer capsules ［J］. Chemistry of Materials, 2009, 21(14): 30423044.

［7］Kawai T, Ohtsuki C, Kamitakahara M, et al. In vitro apatite formation on polyamide containing carboxyl groups modifled with silanol groups ［J］. Journal of Materials Science, 2007, 18(6):10371042.

［8］Matykina E, HernandezLopez J M, Condea A, et al. Morphologies of nanostructured TiO2 doped with F on Ti6Al4V alloy ［J］. Electrochimica Acta, 2011, 56(5): 22212229.

［9］Yang Z P, Si S H, Zeng X M, et al. Mechanism and kinetics of apatite formation on nanocrystalline TiO2 coatings: A quartz crystal microbalance study ［J］. Acta Biomaterialia, 2008(4): 560568．

［10］Ryu J, Ku S H, Lee H, et al. Musselinspired polydopamine coating as a universal route to hydroxyapatite crystallization ［J］. Advanced Functional Materials, 2010, 20(13): 21322139.