In order to design and manufacture a bionic bone scaffold for personalized bone tissue repairing, we
give the performance requirements and indicators, and propose a method of establishing a three-dimensional bone
scaffold solid model based on the Voronoi architecture. The modeling parameters, number of seed points and
scaling factor are found, which can control the model performance. The finite element analysis model of bone
scaffold with different number of seed points and scaling factor is set up. By adopting the method of theory
analysis, experiment and simulation calculation, the performance parameters of the porosity, the specific surface
area and the elastic modulus of 15 sets of bionic bone scaffold model are obtained. The relation between the
bone scaffold model parameters and the porosity, the porosity and the specific surface area, the porosity and the
equivalent elastic modulus are established. The individual design method of Voronoi bone scaffold is proposed.
In the condition of given equivalent elastic modulus and the defected shape of bone, the bone scaffold model
with spatial Voronoi architecture which accords with the performance requirements can be designed and produced
rapidly, which provides reference for the personalized treatment of bone defecting.
WU Li ∗ (武 力), HUANG Wei (黄 伟), LI Xuetao (李学涛)
. Personalized Design Method of Bionic Bone Scaffold with Voronoi Spacial Architecture[J]. Journal of Shanghai Jiaotong University(Science), 2022
, 27(4)
: 521
-527
.
DOI: 10.1007/s12204-022-2410-0
[1] YOO D. New paradigms in internal architecture design and freeform fabrication of tissue engineering poroussc affolds [J]. Medical Engineering and Physics, 2012,34(6): 762-776.
[2] EGAN P F, GONELLA V C, ENGENSPERGER M,et al. Computationally designed lattices with tuned properties for tissue engineering using 3D printing [J].PLoS One, 2017, 12(8): e0182902.
[3] KAPFER S C, HYDE S T, MECKE K, et al. Mini-mal surface scaffold designs for tissue engineering[J].Biomaterials, 2011, 32(29): 6875-6882.
[4] ZHU L Y, LI L, LI Z A, et al. Design and biomechanical characteristics of porous meniscal implant structures using triply periodic minimal surfaces [J]. Journal of Translational Medicine, 2019, 17(1): 89.
[5] W ANG Z, HUANG C, W ANG J, et al. Design and simulation of flow field for bone tissue engineering scaffold based on triply periodic minimal surface[J]. Chinese Journal of Mechanical Engineering, 2019, 32(1): 19.
[6] ZHANG Z Y, ZHAO K, LI Y S, et al. Porous structure design method of bone scaffold based on voxel and triple cycle minimal surfaces [J]. Computer Integrated Manufacturing Systems, 2020, 26(3): 697-706 (in Chinese).
[ 7 ] F E N G J , F U J , S H A N G C , e t a l . P o r o u s s c a ffold de-sign by solid T-splines and triply periodic minimal sur-faces [J]. Computer Methods in Applied Mechanics and Engineering, 2018, 336(7): 333-352.
[8] AHMADI S M, YA V ARI S A, W AUTHLE R, et al.Additively manufactured open-cell porous biomaterials made from six different space-filling unit cells: Themechanical and morphological properties [J]. Materials(Basel), 2015, 8(4): 1871-1896.
[9] KANTAROS A, CHATZIDAI N, KARALEKAS D.3D printing-assisted design of scaffold structures [J].The International Journal of Advanced Manufacturing Technology, 2016, 82(1/2/3/4): 559-571.
[10] ZHAO L, PEI X, JIANG L, et al. Bionic design and 3Dprinting of porous titanium alloy scaffolds for bone tis-sue repair [J]. Composites Part B：Engineering, 2019,162(4): 154-161.
[11] W ANG L, CHEN Q, YARLAGADDA P K D V, etal. Single-parameter mechanical design of a 3D-printedoctet truss topological scaffold to match natural cancellous bones [J]. Materials & Design, 2021, 209(11):109986.
[12] SHIRZAD M, ZOLF AGHARIAN A, MATBOUEI A,et al. Design, evaluation, and optimization of 3Dprinted truss scaffolds for bone tissue engineering [J].Journal of the Mechanical Behavior of Biomedical Materials, 2021, 120(5): 104594.
[13] ZHANG X, TANG L, LIU Z, et al. Yield properties of closed-cell aluminum foam under triaxial loadings bya 3D Voronoi model [J]. Mechanics of Materials, 2017,104(1): 73-84.
[14] CHEN H, LIU Y, W ANG C, et al. Design and properties of biomimetic irregular scaffolds for bone tissue engineering [J]. Computers in Biology and Medicine,2021, 130(3): 104241.
[15] W ANG G, SHEN L, ZHAO J, et al. Design and com-pressive behavior of controllable irregular porous scaffolds: Based on voronoi-tessellation and for additive manufacturing [J]. ACS Biomaterials Science & Engineering, 2018, 4(2): 719-727.
[16] KARAGEORGIOU V, KAPLAN D. Porosity of 3Dbiomaterial scaffolds and osteogenesis [J]. Biomaterials, 2005, 26(27): 5474-5491.
[17] SEVILLA P, APARICIO C, PLANELL J A, et al.Comparison of the mechanical properties between tantalum and nickel-titanium foams implant materials fobone ingrowth applications[J]. Journal of Alloys and Compounds, 2007, 439(1/2): 67-73.
