J Shanghai Jiaotong Univ Sci

Journal of Shanghai Jiaotong University(Science) >

2021 , Vol. 26 >Issue 3: 267 - 271

DOI: https://doi.org/10.1007/s12204-021-2292-6

Medical 3D Printing and Personalised Medicine

3D Printing Bioink Preparation and Application in Cartilage Tissue Reconstruction in Vitro

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  • (Department of Orthopaedic Surgery, Shanghai Key Laboratory of Orthopaedic Implants; Clinical and
    Translational Research Center for 3D Printing Technology, Shanghai Ninth People’s Hospital,
    Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China)

Online published: 2021-06-02

Supported by

the National Key Research and Development
Program of China (Nos. 2018YFB1105600, and
2018YFA0703000), the National Natural Science Foundation
of China (No. 81802131), and the China Postdoctoral
Science Foundation (No. 2019T120347)

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Abstract

Three-dimensional (3D) bioprinting technology has great potential for application in the treatment  of cartilage defects. However, the preparation of biocompatible and stable bioinks is still a major challenge. In  this study, decellularized extracellular matrix (dECM) of soft tissue was used as the basic material to prepare the  bioink. Our results showed that this novel dECM-derived bioink had good printing performance and comprised  a large number of fine nanofibers. Biological characterization revealed that the bioink was compatible with the  growth of chondrocytes and that the nanofibrous structure greatly promoted cell proliferation. Histological and  immunohistochemical analyses showed that the in vitro printed cartilage displayed the presence of characteristic  cartilage lacunae. Thus, a new preparation method for dECM-derived bioink with potential application in generation  of cartilage was developed in this study.

Cite this article

SUN Binbin (孙彬彬), HAN Yu (韩煜), JIANG Wenbo (姜闻博), DAI Kerong(戴尅戎) . 3D Printing Bioink Preparation and Application in Cartilage Tissue Reconstruction in Vitro[J]. Journal of Shanghai Jiaotong University(Science), 2021 , 26(3) : 267 -271 . DOI: 10.1007/s12204-021-2292-6

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