The animal experiment of viscose carbon fiber based C/C composites applied in bone defection intramedullary
fixation was carried out in New Zealand white rabbits. The histological observation on the 100th
day after surgical operation indicated that the experimental animals recovered well and the bone defect area
was reconstructed by new bone trabecula. Immunohistochemical observation of leukocyte common antigen and
macrophage suggested that intramedullary fixation materials did not induct any chronic toxicity reactions such
as inflammatory reactions, macrophage reactions and formation of granulation tissue. The tissue compatibility
of this material was excellent. Meanwhile, the impurity element species and the biological toxic element content
of viscose fiber based C/C composites were determined by atomic fluorescence analyzer and inductively coupled
plasma atomic emission spectrometry. The results reveal that there are few biological toxic elements in the viscose
fiber based C/C composites and it can satisfy the constituent demands of surgical implants.
CAO Ning1* (曹宁), WANG Wen-bo2 (王文波), DONG Jian-wen2 (董建文)
. Animal Experiment of Viscose Carbon Fiber Based C/C Composites
Applied in Bone Fracture Intramedullary Fixation[J]. Journal of Shanghai Jiaotong University(Science), 2012
, 17(5)
: 537
-540
.
DOI: 10.1007/s12204-012-1321-x
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