Unexpected Roles of Long Non-Coding RNAs in Cancer Biology

doi:10.1007/s12204-014-1538-y

Abstract

Abstract: Recent studies show that long non-coding RNAs (lncRNAs) play important roles in the regulation of various biological processes, including chromatin remodeling, dosage-compensation, imprinting, and epigenetic regulation. Aberrant expression of lncRNAs is involved in many complex human diseases, including cancer. In this review, we summarized recent progress on lncRNAs detection methodology with emphasis on their functions and potential implication in cancer diagnosis and therapy.

Key words: long non-coding RNA (lncRNAs)| epigenetics| transcription| carcinomas

摘要： Recent studies show that long non-coding RNAs (lncRNAs) play important roles in the regulation of various biological processes, including chromatin remodeling, dosage-compensation, imprinting, and epigenetic regulation. Aberrant expression of lncRNAs is involved in many complex human diseases, including cancer. In this review, we summarized recent progress on lncRNAs detection methodology with emphasis on their functions and potential implication in cancer diagnosis and therapy.

关键词: long non-coding RNA (lncRNAs)| epigenetics| transcription| carcinomas

CLC Number:

R730.3

QI Yinga (戚颖), KANG Ya-nia,b (康亚妮), ZHAO Xiao-donga,b* (赵晓东). Unexpected Roles of Long Non-Coding RNAs in Cancer Biology[J]. Journal of shanghai Jiaotong University (Science), 2014, 19(5): 544-549.

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