Photoacoustic Imaging by Use of Micro-Electro-Mechanical System Scanner

doi:10.1007/s12204-018-1902-4

摘要/Abstract

摘要： Photoacoustic imaging acquires the absorption contrast of biological tissue with ultrasound resolution. It has been broadly investigated in biomedicine for animal and clinical studies. Recently, a micro-electromechanical system (MEMS) scanner has been utilized in photoacoustic imaging systems to enhance their performance and extend the realm of applications. The review provides a recap of recent developments in photoacoustic imaging using MEMS scanner, from instrumentation to applications. The topics include the design of MEMS scanner, its use in photoacoustic microscopy, miniature imaging probes, development of dual-modality systems, as well as cutting-edge bio-imaging studies.

关键词: photoacoustic imaging, micro-electro-mechanical system (MEMS), photoacoustic microscopy, highspeed imaging, photoacoustic endoscopy

Abstract: Photoacoustic imaging acquires the absorption contrast of biological tissue with ultrasound resolution. It has been broadly investigated in biomedicine for animal and clinical studies. Recently, a micro-electromechanical system (MEMS) scanner has been utilized in photoacoustic imaging systems to enhance their performance and extend the realm of applications. The review provides a recap of recent developments in photoacoustic imaging using MEMS scanner, from instrumentation to applications. The topics include the design of MEMS scanner, its use in photoacoustic microscopy, miniature imaging probes, development of dual-modality systems, as well as cutting-edge bio-imaging studies.

Key words: photoacoustic imaging, micro-electro-mechanical system (MEMS), photoacoustic microscopy, highspeed imaging, photoacoustic endoscopy

中图分类号:

CHEN Sung-Liang (陈松良). Photoacoustic Imaging by Use of Micro-Electro-Mechanical System Scanner[J]. sa, 2018, 23(1): 1-10.

CHEN Sung-Liang (陈松良). Photoacoustic Imaging by Use of Micro-Electro-Mechanical System Scanner[J]. Journal of Shanghai Jiao Tong University (Science), 2018, 23(1): 1-10.

参考文献 42

[1]	XU M, WANG L V. Photoacoustic imaging in biomedicine [J]. Review of Scientific Instruments,2006, 77(4): 041101.
[2]	WANG L V, HU S. Photoacoustic tomography: In vivo imaging from organelles to organs [J]. Science, 2012,335(6075): 1458-1462.
[3]	ZHANG E Z, LAUFER J G, PEDLEY R B, et al.In vivo high-resolution 3D photoacoustic imaging of superficial vascular anatomy [J]. Physics in Medicine and Biology, 2009, 54(4): 1035-1046.
[4]	HU S, WANG L V. Photoacoustic imaging and characterization of the microvasculature [J]. Journal of Biomedical Optics, 2010, 15(1): 011101.
[5]	DE′AN-BEN X L, SELA G, LAURI A, et al. Functional optoacoustic neuro-tomography for scalable wholebrain monitoring of calcium indicators [J]. Light: Science & Applications, 2016, 5: e16201.
[6]	HU S, RAO B, MASLOV K, et al. Label-free photoacoustic ophthalmic angiography [J]. Optics Letters,2010, 35(1): 1-3.
[7]	JIAO S, JIANG M, HU J, et al. Photoacoustic ophthalmoscopy for in vivo retinal imaging [J]. Optics Express,2010, 18(4):3967-3972.
[8]	SETHURAMAN S, AGLYAMOV S R, AMIRIAN J H, et al. Intravascular photoacoustic imaging using an IVUS imaging catheter [J]. IEEE Transactions on Ultrasonics,Ferroelectrics, and Frequency Control, 2007,54(5): 978-986.
[9]	JANSEN K, VAN DER STEEN A F W, VAN BEUSEKOM H M M, et al. Intravascular photoacoustic imaging of human coronary atherosclerosis [J]. Optics Letters, 2011, 36(5): 597-599.
[10]	ZHANG H F, MASLOV K, STOICA G, et al. Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging [J]. Nature Biotechnology,2006, 24(7): 848-851.
[11]	MASLOV K, ZHANG H F, HU S, et al. Opticalresolution photoacoustic microscopy for in vivo imaging of single capillaries [J]. Optics Letters, 2008, 33(9):929-931.
[12]	WANG L V, YAO J. A practical guide to photoacoustic tomography in the life sciences [J]. Nature Methods,2016, 13(8): 627-638.
[13]	HAJIREZA P, SHI W, ZEMP R J. Real-time handheld optical-resolution photoacoustic microscopy [J]. Optics Express, 2011, 19(21): 20097-20102.
[14]	YANG J M, CHEN R, FAVAZZ C, et al. A 2.5-mm diameter probe for photoacoustic and ultrasonic endoscopy [J]. Optics Express, 2012, 20(21): 23944-23953.
[15]	XIE Z, JIAO S, ZHANG H F, et al. Laser-scanning optical-resolution photoacoustic microscopy [J]. Optics Letters, 2009, 34(12): 1771-1773.
[16]	CAI D, LI Z, LI Y, et al. Photoacoustic microscopy in vivo using synthetic-aperture focusing technique combined with three-dimensional deconvolution [J]. Optics Express, 2017, 25(2):1421-1434.
[17]	CAI D, LI Z, CHEN S L. Photoacoustic microscopy by scanning mirror-based synthetic aperture focusing technique [J]. Chinese Optics Letters, 2015, 13(10):101101.
[18]	HU S, MASLOV K, WANG L V. Second-generation optical-resolution photoacoustic microscopy with improved sensitivity and speed [J]. Optics Letters, 2011,36(7): 1134-1136.
[19]	WANG L, MASLOV K, YAO J, et al. Fast voice-coil scanning optical-resolution photoacoustic microscopy[J]. Optics Letters, 2011, 36(2): 139-141.
[20]	LI L, YEH C, HU S, et al. Fully motorized opticalresolution photoacoustic microscopy [J]. Optics Letters,2014, 39(7): 2117-2120.
[21]	DENG P, MA W. Nonlinearity investigation of the MEMS scanning mirror with electrostatic comb drive[C]// Proceedings of the 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS). Hawaii: IEEE, 2014: 212-215.
[22]	NAONO T, FUJII T, ESASHI M, et al. A large-scanangle piezoelectric MEMS optical scanner actuated by a Nb-doped PZT thin film [J]. Journal of Micromechanics and Microengineering, 2014, 24(1): 015010.
[23]	PAN Y, XIE H, FEDDER G K. Endoscopic optical coherence tomography based on a microelectromechanical mirror [J]. Optics Letters, 2001, 26(24): 1966-1968.
[24]	JUNG W, TANG S, MCCORMIC D T, et al. Miniaturized probe based on a microelectromechanical system mirror for multiphoton microscopy [J]. Optics Letters,2008, 33(12): 1324-1326.
[25]	PIYAWATTANAMETHA W, RA H, MANDELLA M J, et al. 3-D near-infrared fluorescence imaging using a mems-based miniature dual-axis confocal microscope[J]. IEEE Journal of Selected Topics in Quantum Electronics,2009, 15(5): 1344-1350.
[26]	QIU Z, PIYAWATTANAMETHA W. New endoscopic imaging technology based on MEMS sensors and actuators[J]. Micromachines, 2017, 8(7): 210.
[27]	XU S, HUANG C H, ZOU J. Microfabricated water-immersible scanning mirror with a small form factor for handheld ultrasound and photoacoustic microscopy [J]. Journal of Micro/Nanolithography,MEMS, MOEMS, 2015, 14(3): 035004.
[28]	HUANG C H, YAO J, WANG L V, et al. A waterimmersible 2-axis scanning mirror microsystem for ultrasound andha photoacoustic microscopic imaging applications [J]. Microsystem Technologies, 2013, 19(4):577-582.
[29]	KIM J Y, LEE C, PARK K, et al. A PDMS-based 2-axis waterproof scanner for photoacoustic microscopy[J]. Sensors, 2015, 15(5): 9815-9826.
[30]	XI L, SUN J, ZHU Y, et al. Photoacoustic imaging based on MEMS mirror scanning [J]. Biomedical Optics Express, 2010, 18(23): 1278-1283.
[31]	CHEN S L, XIE Z, LING T, et al. Miniaturized alloptical photoacoustic microscopy based on microelectromechanical systems mirror scanning [J]. Optics Letters,2012, 37(20): 4263-4265.
[32]	CHEN S L, XIE Z, GUO L J, et al. A fiber-optic system for dual-modality photoacoustic microscopy and confocal fluorescence microscopy using miniature components[J]. Photoacoustics, 2013, 1(2): 30-35.
[33]	LI H, DONG B, ZHANG Z, et al. A transparent broadband ultrasonic detector based on an optical microring resonator for photoacoustic microscopy [J]. Scientific Reports, 2014, 4: 4496.
[34]	YAO J, HUANG C H, WANG L, et al. Wide-field fast-scanning photoacoustic microscopy based on a water-immersible mems scanning mirror [J]. Journal of Biomedical Optics, 2012, 17(8): 080505.
[35]	KIM J Y, LEE C, PARK K, et al. Fast opticalresolution photoacoustic microscopy using a 2-axis water-proofing mems scanner [J]. Scientific Reports,2015, 5: 7932.
[36]	YANG H, XI L, SAMUELSON S, et al. Handheld miniature probe integrating diffuse optical tomography with photoacoustic imaging through aMEMS scanning mirror [J]. Biomedical Optics Express, 2013, 4(3): 427-432.
[37]	LIN L, ZHANG P, XU S, et al. Handheld opticalresolution photoacoustic microscopy [J]. Journal of Biomedical Optics, 2017, 22(4): 041002.
[38]	PARK K, KIM J Y, LEE C, et al. Development of a photoacoustic handheld probe using 2-axis MEMS scanner [C]//Photons Plus Ultrasound: Imaging and Sensing 2017. San Francisco: SPIE, 2017: 100641N.
[39]	KIM S, LEE C, KIM J Y, et al. Two-axis polydimethylsiloxane-based electromagnetic microelectromechanical system scanning mirror for optical coherence tomography [J]. Journal of Biomedical Optics,2016, 21(10): 106001.
[40]	XI L, GROBMYER S R, WU L, et al. Evaluation of breast tumor margins in vivo with intraoperative photoacoustic imaging [J]. Optics Express, 2012, 20(8):8726-8731.
[41]	YAO J, WANG L, YANG J M, et al. High-speed labelfree functional photoacoustic microscopy of mouse brain in action [J]. Nature Methods, 2015, 12(5): 407-410.
[42]	ZHANG H F, MASLOV K, SIVARAMAKRISHNAN M, et al. Imaging of hemoglobin oxygen saturation variations in single vessels in vivo using photoacoustic microscopy [J]. Applied Physics Letters, 2007, 90:053901.