上海交通大学学报(英文版) ›› 2014, Vol. 19 ›› Issue (6): 681-690.doi: 10.1007/s12204-014-1566-7

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Reproducibility in Surface-Enhanced Raman Spectroscopy

XIONG Min (熊敏), YE Jian*(叶坚)   

  1. (Shanghai Engineering Research Center of Medical Device and Technology at Med-X, School of Biomedical Engineering, Shanghai Jiaotong University, Shanghai 200030, China)
  • 出版日期:2014-12-31 发布日期:2014-12-08
  • 通讯作者: YE Jian (叶坚) E-mail:yejian78@sjtu.edu.cn

Reproducibility in Surface-Enhanced Raman Spectroscopy

XIONG Min (熊敏), YE Jian*(叶坚)   

  1. (Shanghai Engineering Research Center of Medical Device and Technology at Med-X, School of Biomedical Engineering, Shanghai Jiaotong University, Shanghai 200030, China)
  • Online:2014-12-31 Published:2014-12-08
  • Contact: YE Jian (叶坚) E-mail:yejian78@sjtu.edu.cn

摘要: Surface-enhanced Raman spectroscopy (SERS) is an intense ongoing hot topic because it is an attractive tool for sensing or detecting molecules in trace amounts. Despite its high specificity and sensitivity, the SERS technique has not been established as a routine analytic method most likely due to the low reproducibility of the SERS signal. This review considers the influence factors to produce the poor reproducibility during the SERS measurement. This review starts with the discussion of calculation of surface-enhanced Raman intensity in order to explain the reason why it is so difficult to achieve a high reproducibility of SERS measurement from the origin of enhancement mechanism. Then we focus on the fabrication of SERS substrates generally including two types: ① single particles and ② arrays on substrate that are directly used to detect molecules or other components. In addition, we discuss the molecule factors and optical system for the reproducibility for sample-to-sample or spot-to-spot on a substrate. In the final part of this review, some effects resulting in the irreproducibility of Raman bands’ position from recent literatures are discussed.

关键词: surface-enhanced Raman spectroscopy (SERS), reproducibility, Raman intensity, Raman shift, plasmonic nanoparticle

Abstract: Surface-enhanced Raman spectroscopy (SERS) is an intense ongoing hot topic because it is an attractive tool for sensing or detecting molecules in trace amounts. Despite its high specificity and sensitivity, the SERS technique has not been established as a routine analytic method most likely due to the low reproducibility of the SERS signal. This review considers the influence factors to produce the poor reproducibility during the SERS measurement. This review starts with the discussion of calculation of surface-enhanced Raman intensity in order to explain the reason why it is so difficult to achieve a high reproducibility of SERS measurement from the origin of enhancement mechanism. Then we focus on the fabrication of SERS substrates generally including two types: ① single particles and ② arrays on substrate that are directly used to detect molecules or other components. In addition, we discuss the molecule factors and optical system for the reproducibility for sample-to-sample or spot-to-spot on a substrate. In the final part of this review, some effects resulting in the irreproducibility of Raman bands’ position from recent literatures are discussed.

Key words: surface-enhanced Raman spectroscopy (SERS), reproducibility, Raman intensity, Raman shift, plasmonic nanoparticle

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