Journal of Shanghai Jiao Tong University

Journal of Shanghai Jiaotong University >

2021 , Vol. 55 >Issue 9: 1151 - 1157

DOI: https://doi.org/10.16183/j.cnki.jsjtu.2020.196

Biocompatibility and Biosafety Analysis of Transcutaneous Energy Transfer System of Artificial Anal Sphincter

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  • Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai 200240, China

Received date: 2020-06-30

  Online published: 2021-10-08

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Abstract

The biosafety and biocompatibility after implantation of the transcutaneous energy transfer system of artificial anal sphincter is verified by combining simulation and experiment in this paper. The biosafety study is based on the simulation of bioelectromagnetic radiation experiment and the thermal rise during the charging period while the biocompatibility study is based on the coloration experiment of the tissue around the energy supply system during the in vivo experiment. The results of biosafety indicate that the transcutaneous energy transfer system performs excellently in bioelectromagnetic safety in the experimental environment with a resonance frequency of 110 kHz and an output power of 10 W. In addition, the local specific absorption rate is far below the international human electromagnetic safety standard. After 30 minutes of fast charging, the system temperature increases by 2.81 ℃, which is lower than the temperature threshold of 4.8 ℃, demonstrating the outstanding biothermal safety of the system. The section staining experiment of the wireless energy supply system indicates that the poly-ether-ether-ketone (PEEK) shell can significantly reduce immune rejection and improve the biocompatibility of the system.

Key words： artificial anal sphincter; biocompatibility; biosafety

Cite this article

YANG Chen, YAN Guozheng, ZHOU Zerun, HUA Fangfang . Biocompatibility and Biosafety Analysis of Transcutaneous Energy Transfer System of Artificial Anal Sphincter[J]. Journal of Shanghai Jiaotong University, 2021 , 55(9) : 1151 -1157 . DOI: 10.16183/j.cnki.jsjtu.2020.196

References

[1] SAINSBURY A, HEATLEY R V. Review article: Psychosocial factors in the quality of life of patients with inflammatory bowel disease[J]. Alimentary Pharmacology & Therapeutics, 2005, 21(5):499-508.
[2] PRETLOVE S J, RADLEY S, TOOZS-HOBSON P M, et al. Prevalence of anal incontinence according to age and gender: A systematic review and meta-regression analysis[J]. International Urogynecology Journal, 2006, 17(4):407-417.
[3] GUINANE J. Management of faecal incontinence in residential aged care[J]. Australian Journal of General Practice, 2018, 47(1/2):40-42.
[4] FERNANDO R, SULTAN A H, KETTLE C, et al. Methods of repair for obstetric anal sphincter injury[J]. The Cochrane Database of Systematic Reviews, 2006(3): CD002866.
[5] GLASGOW S C, LOWRY A C. Long-term outcomes of anal sphincter repair for fecal incontinence: A systematic review[J]. Diseases of the Colon & Rectum, 2012, 55(4):482-490.
[6] ZHOU M W, WANG Z H, CHEN Z Y, et al. Advantages of early preventive ileostomy closure after total mesorectal excision surgery for rectal cancer: An institutional retrospective study of 123 consecutive patients[J]. Digestive Surgery, 2017, 34(4):305-311.
[7] SOERENSEN M M, PEDERSEN B G, SANTORO G A, et al. Long-term function and morphology of the anal sphincters and the pelvic floor after primary repair of obstetric anal sphincter injury[J]. Colorectal Disease, 2014, 16(10):O347-O355.
[8] KAGA T, SHIBA K J. Measurement of energy transmission efficiency of transcutaneous energy transformer in NaCl solution for ventricular assist devices by reducing common-mode current in the range of 200—1500 kHz[C]// 2017 IEEE Biomedical Circuits and Systems Conference (BioCAS). Turin, Italy: IEEE, 2017: 17681168.
[9] 昝鹏, 张春东, 刘颜凯, 等. 基于经皮能量传输的人工肛门括约肌生物电磁相容性研究[J]. 上海交通大学学报, 2018, 52(8):997-1002.
[9] ZAN Peng, ZHANG Chundong, LIU Yankai, et al. Research on bio-electromagnetic compatibility of artificial anal sphincter based on transcutaneous energy transfer[J]. Journal of Shanghai Jiao Tong University, 2018, 52(8):997-1002.
[10] XIAO C Y, CHENG D N, WEI K Z. An LCC-C compensated wireless charging system for implantable cardiac pacemakers: Theory, experiment, and safety evaluation[J]. IEEE Transactions on Power Electronics, 2018, 33(6):4894-4905.
[11] ZHOU Z R, YAN G Z, WANG Z W, et al. A novel power supply system for puborectalis-like artificial anal sphincter[J]. Artificial Organs, 2019, 43(6):E109-E123.
[12] KRITIKOS H N, FOSTER K R, SCHWAN H P. Temperature profiles in spheres due to electromagnetic heating[J]. Journal of Microwave Power, 1981, 16(3/4):327-344.
[13] FOSTER K R. Thermal effects of microwave and radiofrequency radiation[M]// Non-ionizing Radiation Protection. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2017: 163-185.
[14] WU J, LEI Y Z. Analytical expression to impedance for solenoid coil with a coaxial cylindrical ferrite core of finite length[J]. Journal of Physics D: Applied Physics, 2002, 35(6):570-575.
[15] ZHANG S X, HENG P A, LIU Z J. Chinese visible human project[J]. Clinical Anatomy: The Official Journal of the American Association of Clinical Anatomists and the British Association of Clinical Anatomists, 2006, 19(3):204-215.
[16] REPACHOLI M H, GRANDOLFO M, AHLBOM A, et al. Health issues related to the use of hand-held radiotelephones and base transmitters[J]. Health Physics, 1996, 70(4):587-593.
[17] OZOVEHE A, IBRAHIM M, HAMDALLAH A. Analysis of electromagnetic pollution due to high voltage transmission lines[J]. Journal of Energy Technologies and Policy, 2012, 2(7):1-11.
[18] BASAR M, AHMAD M, CHO J, et al. Application of wireless power transmission systems in wireless capsule endoscopy: An overview[J]. Sensors, 2014, 14(6):10929-10951.
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