Therapeutic glycoproteins show the advantages of specificity, outstanding curative effect, and good safety in many diseases. Glycosylation is an important factor affecting molecular stability, immunogenicity, and pharmacokinetic profiles. By means of glycoengineering strategies, researches on the evolution of glycan on therapeutic glycoproteins have deepened. This paper briefly describes the production and modification of recombinant glycoproteins in vivo or vitro, and indicates that the production of homogeneous glycoprotein is the prerequisite for studying the effect of glycan on therapeutic glycoprotein properties.
ZHANG Han,ZHANG Yan
. Production and Glycan Evolution of Therapeutic Glycoproteins[J]. Journal of Shanghai Jiaotong University, 2021
, 55(Sup.1)
: 41
-43
.
DOI: 10.16183/j.cnki.jsjtu.2021.S1.037
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