This paper studied the effects of indoor lighting illuminant on human thermoregulation at different air temperature. 8 student-volunteers participated in this experiment in an artificial climate chamber. The experimental conditions consisted of 8 effectors provided by a combinations of 2 levels of air temperature（18 °C and 30 °C），2 levels of color temperature (3 000 K and 6 000 K) and 2 levels of illuminance (300 lx and  1000 lx). The rectal temperature, mean skin temperature and skin blood flow were recorded under each condition for 60 min. The results showed that at both  high and low air temperatures, when exposed at  low color temperature lighting, the rectal temperature was   higher than high color temperature, but at a lower temperature, the mean skin temperature and skin blood flow were higher than low color temperature lighting. Under different ambient temperature, illumination plays a certain role for human thermal regulation. During the high ambient temperature, it is appropriate to use of high color temperature lighting, and vice versa. Therefore, the selection of a proper color temperature lighting is of great importance for human beings in different environmental temperatures.