Abstract: In order to solve the problems of rapid prototyping and realtime communication between distributed nodes in the system of hardwareintheloop (HIL), a resolution of combination of xPC target and reflective memory network (RMN) was proposed. A design procedure of HIL test and the key technique of building realtime network using RMN were introduced under the environment of xPC target. Performance measurements on singlepoint xPC target and multipoint xPC targets connected with RMN were also carried out. Through the application in certain terminal guidance simulation system, the “xPC + RMN” based solution is proved to be suitable for the development of HIL.