Abstract: Nonlinear dynamical finite element method was applied to simulate the damage effect of bridge subjected to blast wave. Histories of blast wave propagation and overpressures were obtained. Through the comparison between the calculation results and the experimental values, the reliability of the calculation was validated. Then the dynamic responses of bridge subjected to blast wave were studied. The calculation results show that the limited areas of bridge，with large local damage in regions which are near blast，act with blast wave. The simulation results provide important reference for the calculation of blast resistant loads and evaluation of bridge safety.