氟化在改善缺钙型羟基磷灰石的热稳定性的同时，可以保持材料原有的良好生物相容性和生物活性.在同等化学沉淀条件下，通过X射线衍射(XRD)表征，在氟加入量不同时，研究合成产物及其热稳定性.不添加氟，合成产物主要为二水合磷酸氢钙(DCPD)，并含极少量羟基磷灰石(HA)；加入少量氟，合成产物为DCPD和缺钙型氟化羟基磷灰石(D-FHA)混合物；随着氟含量提高，样品04F的合成产物中DCPD消失，仅剩D-FHA，可见氟在这一合成反应过程中促进了DCPD向D-FHA的转变.对合成产物进行煅烧的结果表明：加热温度为200℃时，只有无氟和02F这两种样品发生脱羟基反应，在氟含量继续增加时，该反应消失；加热温度为600℃时，04F样品中的D-FHA开始分解为β-Ca3(PO4)2和β-Ca2P2O7两种磷酸钙，继续增加氟含量时发生这一分解的温度升高，可见D-FHA的稳定性提高.
Fluoridating holds considerable promising for improving thermos stability of calcium-deficient hydroxyapatite with reserving pristine good biocompatibility and bio-activity. In this paper, synthetic products and their thermo stability are studied with different fluorine additions under the same chemical precipitation condition by X-ray diffraction (XRD). Dicalcium phosphate dihydrate (DCPD) is the main product with few hydroxyapatite (HA) when no fluorine is added; mixture of calcium-deficient fluoridated hydroxyapatite (D-FHA) and DCPD appears in products when fluorine is added, and only D-FHA remains in products of Sample 04F. Influence of fluorine on the synthetic process is proved to accelerate the transformation from DCPD to D-FHA. Synthetic products are further sintered to investigate the thermo stability. Dehydration occurs only in Sample 00F and Sample 02F when heated at 200℃, which does not appear in Samples 04F—10F. D-FHA of Sample 04F begins to decompose into β-Ca3(PO4)2 and β-Ca2P2O7 at 600℃. The temperature of D-FHA decomposition rises and the stability improves with the increasing fluorine addition.
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