数字赋能,医工破局:四肢骨关节炎数字化诊疗关键技术的创新与启示(特邀)

doi:10.16183/j.cnki.jsjtu.2026.066

上海交通大学学报 ›› 2026, Vol. 60 ›› Issue (3): 349-354.doi: 10.16183/j.cnki.jsjtu.2026.066

• 特邀专栏 • 下一篇

数字赋能,医工破局:四肢骨关节炎数字化诊疗关键技术的创新与启示(特邀)

唐佩福¹(), 李国安²(), 刘朝宗³(), 宋志坚⁴()

¹ 解放军总医院骨科医学部, 北京 100853
² 哈佛医学院牛顿韦尔斯利医院骨科生物工程研究中心骨科手术部, 牛顿 MA 02462, 美国
³ 伦敦大学学院骨科与肌肉骨骼科学研究所, 伦敦 HA7 4LP, 英国
⁴ 复旦大学基础医学院数字医学研究中心, 上海 200032

收稿日期:2026-02-20 修回日期:2026-03-10 接受日期:2026-03-25 出版日期:2026-03-28 发布日期:2026-03-30
作者简介:唐佩福,中国工程院院士,中国人民解放军总医院骨科医学部主任,专业技术少将、主任医师、教授、博士生导师.骨创伤与军事医学专家,擅长严重骨创伤修复重建;E-mail:tangpeifu@301hospital.com.cn.
李国安,美国哈佛大学医学院副教授和Newton-Wellesley医院骨科生物力学与创新中心主任,长期从事骨科临床与基础生物力学的研究;E-mail:guoanli12@gmail.com.
刘朝宗,英国伦敦大学学院骨科与肌肉骨骼科学研究所教授,生物医学工程与人工关节科学研究中心主任,研究方向主要包括生物材料创新研究、骨科疾病治疗、骨骼组织修复与再生的高效医疗器械的研发等;E-mail:chaozong.liu@ucl.ac.uk.
宋志坚,复旦大学数字医学研究中心主任、上海市MICCAI(Medical Image Computing and Computer Assisted Intervention)重点实验室主任,主要研究方向为虚拟现实技术在医学中的应用与计算机辅助诊断与治疗;E-mail:zjsong@fudan.edu.cn.
基金资助:
国家科技部重点研发计划(SQ2018YFB110094);上海市优秀技术带头人计划(19XD1434200)

Digitally Empowered Medical-Engineering Innovation: Key Technologies and Implications for Digital Diagnosis and Treatment of Limb Osteoarthritis (Invited)

TANG Peifu¹(), LI Guo'an²(), LIU Chaozong³(), SONG Zhijian⁴()

¹ Senior Department of Orthopedics, Chinese PLA General Hospital, Beijing 100853, China
² Orthopaedic Bioengineering Research Center, Department of Orthopaedic Surgery, Newton-Wellesley Hospital, Harvard Medical School, Newton MA 02462, USA
³ Institute of Orthopaedic and Musculoskeletal Science, University College London, London HA7 4LP, UK
⁴ Digital Medical Research Center, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China

Received:2026-02-20 Revised:2026-03-10 Accepted:2026-03-25 Online:2026-03-28 Published:2026-03-30

摘要/Abstract

摘要：

系统评述了王金武教授团队在四肢骨关节炎(osteoarthritis, OA)数字化诊疗领域取得的突破性成果.针对传统OA诊疗面临的早期筛查难、阶梯治疗缺乏生物力学适配及术后康复脱节等痛点,该团队立足医工交叉与数字赋能,构建OA“筛-治-康”新模式.项目研发了双平面荧光透视系统,实现动态精准筛查;提出“关节减荷力学矫治”理论,结合3D打印个性化矫形器、干细胞富集技术及定制假体实现精准治疗;首创基于物联网的远程云康复网络.该体系在微观代谢机制的耦合及产业化降本方面仍有优化空间,但未来若深度融合类器官与数字孪生等前沿技术,必将推动OA诊疗迈向多维精准的新阶段,彰显医工交叉赋能人类健康的深远价值.

关键词: 骨关节炎, 医工交叉, 数字化医疗, 3D打印

Abstract:

This paper systematically reviews the breakthrough achievements of Professor Wang Jinwu’s research team in digital diagnosis and treatment of limb osteoarthritis (OA). Addressing key challenges in conventional OA management, such as difficulties in early screening, the lack of biomechanically adaptive stepwise treatment strategies, and the disconnect between surgery and postoperative rehabilitation, the team has developed a novel “screening-treatment-rehabilitation” model through interdisciplinary integration of medicine and engineering supported by digital technologies. Specifically, they developed a biplanar fluoroscopy system for precise dynamic screening, proposed the theory of “joint unloading mechanical correction”, and implemented precision treatment through the integration of 3D-printed personalized orthoses, stem cell enrichment techniques, and customized prostheses. In addition, they pioneered an Internet of Things (IoT)-based remote cloud rehabilitation network. Although this framework still requires further optimization regarding micro-metabolic mechanism coupling and industrial cost reduction, deeper integration with cutting-edge technologies such as organoids and digital twins in the future is expected to drive OA diagnosis and treatment toward a new stage of multidimensional precision medicine, demonstrating the profound value of medical-engineering integration in advancing human health.

Key words: osteoarthritis (OA), medical-engineering integration, digital medicine, 3D printing

中图分类号:

R684.3

唐佩福, 李国安, 刘朝宗, 宋志坚. 数字赋能,医工破局:四肢骨关节炎数字化诊疗关键技术的创新与启示(特邀)[J]. 上海交通大学学报, 2026, 60(3): 349-354.

TANG Peifu, LI Guo'an, LIU Chaozong, SONG Zhijian. Digitally Empowered Medical-Engineering Innovation: Key Technologies and Implications for Digital Diagnosis and Treatment of Limb Osteoarthritis (Invited)[J]. Journal of Shanghai Jiao Tong University, 2026, 60(3): 349-354.

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数字赋能,医工破局:四肢骨关节炎数字化诊疗关键技术的创新与启示(特邀)

Digitally Empowered Medical-Engineering Innovation: Key Technologies and Implications for Digital Diagnosis and Treatment of Limb Osteoarthritis (Invited)

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