上海交通大学学报

上海交通大学学报 ›› 2026, Vol. 60 ›› Issue (4): 523-530.doi: 10.16183/j.cnki.jsjtu.2026.105

• 特邀专栏 •    下一篇

超声成像与调控融合路径的突破与启示——评超声脑机接口闭环体系构建的相关研究(特邀)

徐天乐(), 高郑润, 季诚昕   

  1. 上海交通大学医学院 松江研究院, 上海 201600
  • 收稿日期:2026-03-09 修回日期:2026-03-28 接受日期:2026-04-02 出版日期:2026-04-28 发布日期:2026-04-29
  • 作者简介:徐天乐(1965—),上海交通大学特聘教授,上海交通大学医学院松江研究院执行院长,长期从事离子通道与神经环路机制研究,聚焦脑卒中及情感障碍开发精准神经调控新技术;E-mail: xu-happiness@shsmu.edu.cn.
    高郑润,研究员,长期致力于物理场调控与超声脑机接口研究;
    季诚昕,硕士生,专注基于超声的脑机交互与神经调控研究.
  • 基金资助:
    “脑科学与类脑计划”国家科技重大专项(青年科学家B类项目);“脑科学与类脑计划”国家科技重大专项(2025ZD0218600)

Breakthroughs and Implications in the Integration Pathways of Ultrasound Imaging and Modulation: A Review of Studies on the Construction of a Closed-Loop Ultrasound Brain-Computer Interface System (Invited)

XU Tianle(), GAO Zhengrun, JI Chengxin   

  1. Songjiang Research Institute, Shanghai Jiao Tong University School of Medicine, Shanghai 201600, China
  • Received:2026-03-09 Revised:2026-03-28 Accepted:2026-04-02 Online:2026-04-28 Published:2026-04-29

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摘要：

超声技术正在突破传统影像技术的功能边界,逐步形成兼具脑状态读取、精准调控与系统集成的新体系.本文聚焦郑元义教授团队在超声断层成像(ultrasound tomography, UT)、超声定位显微成像(ultrasound localization microscopy, ULM)、低强度脉冲超声(low-intensity pulsed ultrasound, LIPUS)调控及可穿戴超声系统等方面的代表性进展,梳理其由单一成像诊断向“感知—调控—反馈”闭环架构演进的技术逻辑.其关键贡献在于提出以统一声学载体为基础的超声脑机接口(ultrasound brain-computer interface, U-BCI)思路,推动超声由辅助诊疗工具转向脑机交互介质.这一路径为无创深部神经调控、连续生理监测及院内外一体化干预提供了新框架,也为脑机接口临床转化与神经干预技术发展提供了新方向.

关键词: 神经超声, 超声脑机接口, 闭环体系, 非侵入式神经调控, 医工交叉

Abstract:

Ultrasound technology is moving beyond the functional limits of traditional imaging and modalities, gradually developing into a new paradigm that integrates brain-state sensing, precise modulation, and system integration. This paper focuses on the representative advances made by Professor Zheng Yuanyi’s team in ultrasound tomography (UT), ultrasound localization microscopy (ULM), low-intensity pulsed ultrasound (LIPUS) neuromodulation, and wearable ultrasound systems. It systematically analyzes the technological evolution from single-modality imaging diagnostics to a closed-loop framework of “sensing—modulation—feedback”. A key contribution of this paper lies in the proposal of an ultrasound brain-computer interface (U-BCI) framework based on a unified acoustic carrier, promoting ultrasound from an auxiliary diagnostic and therapeutic tool to a medium for brain-computer interaction. This pathway provides a new framework for noninvasive deep neuromodulation, continuous physiological monitoring, and integrated in-hospital and out-of-hospital interventions, and offers a new direction for the clinical translation of brain-computer interfaces and the advancement of neurointerventional technologies.

Key words: neuro-ultrasound, ultrasound brain-computer interface (U-BCI), closed-loop framework, noninvasive neuromodulation, medical-engineering integration

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