上海交通大学学报 ›› 2021, Vol. 55 ›› Issue (9): 1058-1063.doi: 10.16183/j.cnki.jsjtu.2021.038
所属专题: 《上海交通大学学报》2021年12期专题汇总专辑; 《上海交通大学学报》2021年“化学化工”专题
收稿日期:
2021-02-05
出版日期:
2021-09-28
发布日期:
2021-10-08
通讯作者:
张书宇
E-mail:zhangsy16@sjtu.edu.cn
作者简介:
谭富欣(1995-),男,河南省南阳市人,硕士生,主要从事有机合成方法学的研究
基金资助:
TAN Fuxin, LI Zihao, ZHOU Jia, ZHANG Shuyu()
Received:
2021-02-05
Online:
2021-09-28
Published:
2021-10-08
Contact:
ZHANG Shuyu
E-mail:zhangsy16@sjtu.edu.cn
摘要:
为将C-H活化策略应用于手性有机催化剂的开发,选择以L-脯氨酸为原料、C(sp3)-H硅烷化反应为关键步骤,设计合成了两种新型的C3-三甲基硅基取代的手性脯氨酸催化剂,并将其分别应用于对硝基苯甲醛与丙酮的分子间不对称aldol反应和亚胺与β-甲基丁醛的分子间不对称Mannich反应,均可以良好对映选择性实现目标产物的合成.该策略有效丰富了脯氨酸结构的修饰手段,为新型含硅小分子催化剂的开发提供了新方法.
中图分类号:
谭富欣, 李子昊, 周佳, 张书宇. 新型C3-含硅基取代手性脯氨酸型催化剂的高效构筑[J]. 上海交通大学学报, 2021, 55(9): 1058-1063.
TAN Fuxin, LI Zihao, ZHOU Jia, ZHANG Shuyu. Efficient Construction of Novel C3-Silyl Substituted Chiral Proline Catalysts[J]. Journal of Shanghai Jiao Tong University, 2021, 55(9): 1058-1063.
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[1] | 练鹏飞, 王训辉, 张书宇. 基于惰性C(sp3)-H胺化反应设计合成新型伯胺-硫脲有机催化剂[J]. 上海交通大学学报, 2020, 54(12): 1335-1339. |
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