上海交通大学学报 ›› 2021, Vol. 55 ›› Issue (Sup.1): 41-43.doi: 10.16183/j.cnki.jsjtu.2021.S1.037

所属专题: 上海交通大学建校125周年科学问题专辑

• 医学科学 • 上一篇    下一篇

糖蛋白药物的生产与糖链改造

张涵,张延   

  1. 上海交通大学 系统生物医学研究院,上海 200240
  • 收稿日期:2021-02-03 出版日期:2021-03-28 发布日期:2021-04-09
  • 通讯作者: 张延,女,教授,博士生导师,电话(Tel.):021-34206778;E-mail:yanzhang2006@sjtu.edu.cn.
  • 作者简介:张涵(1997-),女,黑龙江省牡丹江市人,博士生,从事糖生物学与糖工程研究.

Production and Glycan Evolution of Therapeutic Glycoproteins

ZHANG Han,ZHANG Yan   

  1. Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China
  • Received:2021-02-03 Online:2021-03-28 Published:2021-04-09

摘要: 糖蛋白药物在多种疾病中显示出靶点特异、疗效突出和安全性好等优点,其糖基化是影响药物半衰期、免疫原性和药代动力学等的重要因素.糖工程促进糖蛋白药物上糖链的改造和优化研究逐渐深入.本文简述重组糖蛋白药物在细胞内或体外的合成和糖链改造,并指出生产均一化糖蛋白是研究糖链对药物性质影响的前提和基础.

关键词: 糖蛋白药物;糖链均一性

Abstract: Therapeutic glycoproteins show the advantages of specificity, outstanding curative effect, and good safety in many diseases. Glycosylation is an important factor affecting molecular stability, immunogenicity, and pharmacokinetic profiles. By means of glycoengineering strategies, researches on the evolution of glycan on therapeutic glycoproteins have deepened. This paper briefly describes the production and modification of recombinant glycoproteins in vivo or vitro, and indicates that the production of homogeneous glycoprotein is the prerequisite for studying the effect of glycan on therapeutic glycoprotein properties.

Key words: therapeutic glycoprotein; homogeneous glycan

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